Epileptogenic networks are defined by the brain regions involved in the production and
propagation of epileptic activities. In this review we describe the historical, methodologic …

Individuals with drug-resistant focal epilepsy are candidates for surgical treatment as a
curative option. Before surgery can take place, the patient must have a presurgical …

Precise estimates of epileptogenic zone networks (EZNs) are crucial for planning
intervention strategies to treat drug-resistant focal epilepsy. Here, we present the virtual …

Defining a bio-electrical marker for the brain area responsible for initiating a seizure remains
an unsolved problem. Fast gamma activity has been identified as the most specific marker …

Abstract The International League Against Epilepsy (ILAE) defined a seizure as “a transient
occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal …

Objective The virtual epileptic patient (VEP) is a large‐scale brain modeling method based
on virtual brain technology, using stereoelectroencephalography (SEEG), anatomical data …

Over 15 million patients with epilepsy worldwide do not respond to drugs. Successful
surgical treatment requires complete removal or disconnection of the seizure onset zone …

See Bear and Kirsch (doi: 10.1093/aww248) for a scientific commentary on this article.
Magnetoencephalography and stereo-electroencephalography are often necessary in the …

Abnormally enhanced glutamatergic excitation is commonly believed to mark the onset of a
focal seizure. This notion, however, is not supported by firm evidence, and it will be …

Objective Stereoelectroencephalography (SEEG) is the reference method in the presurgical
exploration of drug‐resistant focal epilepsy. However, prognosticating surgery on an …