Background Mitochondrial uncouplers are well-known for their ability to treat a myriad of
metabolic diseases, including obesity and fatty liver diseases. However, for many years now …

Restoring innate apoptosis and simultaneously inhibiting metastasis by a molecular drug is
an effective cancer therapeutic approach. Herein, a large rigid and V-shaped NIR-II dye …

Over the last decades a renewed interest in n− 3 very long polyunsaturated fatty acids
(PUFAs), derived mainly from fish oils in the human diet, has been observed because of …

Recently, we reported that N-acetyltransferase 10 (NAT10) regulates fatty acid metabolism
through ac4C-dependent RNA modification of key genes in cancer cells. During this work …

Respiring mitochondria establish a proton gradient across the mitochondrial inner
membrane (MIM) that is used to generate ATP. Protein-independent mitochondrial …

The cancer cell mitochondrion is functionally different from that in normal cells and could be
targeted to develop novel experimental therapeutics. The aryl-ureido fatty acid CTU (16 ({[4 …

Lipid-based drugs are emerging as an interesting class of novel anticancer drugs with the
potential to target specific cancer cell metabolic pathways linked to their proliferation and …

Current treatment options for triple-negative breast cancer (TNBC) are limited to toxic drug
combinations of low efficacy. We recently identified an aryl-substituted fatty acid analogue …

Introduction ω-3 Polyunsaturated fatty acids (PUFAs) have a range of health benefits,
including anticancer activity, and are converted to lipid mediators that could be adapted into …

Pancreatic ductal adenocarcinoma (PDAC)'s resistance to therapies is mainly attributed to
pancreatic cancer stem cells (PCSCs). Mitochondria-impairing agents can be used to …