Antimicrobial peptides and copper (II) ions: Novel therapeutic opportunities
J Portelinha, SS Duay, SI Yu, K Heilemann… - Chemical …, 2021 - ACS Publications
The emergence of new pathogens and multidrug resistant bacteria is an important public
health issue that requires the development of novel classes of antibiotics. Antimicrobial …
health issue that requires the development of novel classes of antibiotics. Antimicrobial …
Dipolar Recoupling in Rotating Solids
Magic angle spinning (MAS) nuclear magnetic resonance (NMR) has evolved significantly
over the past three decades and established itself as a vital tool for the structural analysis of …
over the past three decades and established itself as a vital tool for the structural analysis of …
Antiviral activity of the host defense peptide piscidin 1: investigating a membrane-mediated mode of action
Outbreaks of viral diseases are on the rise, fueling the search for antiviral therapeutics that
act on a broad range of viruses while remaining safe to human host cells. In this research …
act on a broad range of viruses while remaining safe to human host cells. In this research …
Host Defense Peptide Piscidin and Yeast-Derived Glycolipid Exhibit Synergistic Antimicrobial Action through Concerted Interactions with Membranes
Developing new antimicrobials as alternatives to conventional antibiotics has become an
urgent race to eradicate drug-resistant bacteria and to save human lives. Conventionally …
urgent race to eradicate drug-resistant bacteria and to save human lives. Conventionally …
How functional lipids affect the structure and gating of mechanosensitive MscS-like channels
VJ Flegler, T Rasmussen, B Böttcher - International Journal of Molecular …, 2022 - mdpi.com
The ability to cope with and adapt to changes in the environment is essential for all
organisms. Osmotic pressure is a universal threat when environmental changes result in an …
organisms. Osmotic pressure is a universal threat when environmental changes result in an …
Copper-binding anticancer peptides from the piscidin family: an expanded mechanism that encompasses physical and chemical bilayer disruption
In the search for novel broad-spectrum therapeutics to fight chronic infections, inflammation,
and cancer, host defense peptides (HDPs) have garnered increasing interest …
and cancer, host defense peptides (HDPs) have garnered increasing interest …
The bright and dark sides of reactive oxygen species generated by copper–peptide complexes
UK Komarnicka, MK Lesiów, M Witwicki, A Bieńko - Separations, 2022 - mdpi.com
Copper ions bind to biomolecules (eg, peptides and proteins) playing an essential role in
many biological and physiological pathways in the human body. The resulting complexes …
many biological and physiological pathways in the human body. The resulting complexes …
Approaches for the modulation of mechanosensitive MscL channel pores
MscL was the first mechanosensitive ion channel identified in bacteria. The channel opens
its large pore when the turgor pressure of the cytoplasm increases close to the lytic limit of …
its large pore when the turgor pressure of the cytoplasm increases close to the lytic limit of …
[HTML][HTML] Enhancing the membrane activity of Piscidin 1 through peptide metallation and the presence of oxidized lipid species: Implications for the unification of host …
Piscidins are host-defense peptides (HDPs) from fish that exhibit antimicrobial, antiviral, anti-
cancer, anti-inflammatory, and wound-healing properties. They are distinctively rich in …
cancer, anti-inflammatory, and wound-healing properties. They are distinctively rich in …
Roles of bacterial mechanosensitive channels in infection and antibiotic susceptibility
M Sidarta, L Baruah, M Wenzel - Pharmaceuticals, 2022 - mdpi.com
Bacteria accumulate osmolytes to prevent cell dehydration during hyperosmotic stress. A
sudden change to a hypotonic environment leads to a rapid water influx, causing swelling of …
sudden change to a hypotonic environment leads to a rapid water influx, causing swelling of …