Pneumoviruses are single-stranded, negative-sense, nonsegmented RNA viruses of the
family Paramyxoviridae, subfamily Pneumovirinae, and include pathogens that infect …

Highlights•X-ray crystal structures of prefusion and postfusion RSV F have been
determined.•Antibodies specific for the prefusion conformation are extremely potent.•Select …

Technologies that define the atomic-level structure of neutralization-sensitive epitopes on
viral surface proteins are transforming vaccinology and guiding new vaccine development …

The prefusion state of respiratory syncytial virus (RSV) fusion (F) glycoprotein is the target of
most RSV-neutralizing activity in human sera, but its metastability has hindered …

Respiratory syncytial virus (RSV) is an important causative agent of lower respiratory tract
infections in infants and elderly individuals. Its fusion (F) protein is critical for virus infection. It …

Respiratory syncytial virus (RSV) invades host cells via a type I fusion (F) glycoprotein that
undergoes dramatic structural rearrangements during the fusion process. Neutralizing …

Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in young
children and the elderly. There are currently no licensed RSV vaccines, and passive …

Human respiratory syncytial virus (hRSV) is the most important viral agent of pediatric
respiratory infections worldwide. The only specific treatment available today is a humanized …

Respiratory syncytial virus (RSV), the main cause of infant bronchiolitis, remains a major
unmet vaccine need despite more than 40 years of vaccine research. Vaccine candidates …

Respiratory syncytial virus (RSV) infection is the leading cause of hospitalization and infant
mortality under six months of age worldwide; therefore, the prevention of RSV infection in all …