DNA is continuously attacked by reactive species that can affect its structure and function
severely. Structural modifications to DNA mainly arise from modifications in its bases that …

The nucleoside inosine plays an important role in purine biosynthesis, gene translation, and
modulation of the fate of RNAs. The editing of adenosine to inosine is a widespread post …

Applications of adenine base editors (ABEs) have been constrained by the limited
compatibility of the deoxyadenosine deaminase component with Cas homologs other than …

CRISPR-Cas–guided base editors convert A• T to G• C, or C• G to T• A, in cellular DNA for
precision genome editing. To understand the molecular basis for DNA adenosine …

Naturally occurring modification of the canonical A, G, C, and T bases can be found in the
DNA of cellular organisms and viruses from all domains of life. Bacterial viruses …

The DNA damage response (DDR) is an organized network of multiple interwoven
components evolved to repair damaged DNA and maintain genome fidelity. Conceptually …

Endonuclease V orthologues are highly conserved proteins found in all kingdoms of life.
While the prokaryotic enzymes are DNA repair proteins for removal of deaminated …

Deamination of the nucleobases in DNA and RNA is a result of spontaneous hydrolysis,
endogenous or environmental factors as well as deaminase enzymes. Adenosine is …

Helicases must unwind DNA at the right place and time to maintain genomic integrity or
gene expression. Biologically critical XPB and XPD helicases are key members of the …

Endogenous DNA damage induced by hydrolysis, reactive oxygen species and alkylation
modifies DNA bases and the structure of the DNA duplex. Numerous mechanisms have …