[HTML][HTML] Lenvatinib for hepatocellular carcinoma: From preclinical mechanisms to anti-cancer therapy

Y Zhao, YN Zhang, KT Wang, L Chen - Biochimica et Biophysica Acta (BBA …, 2020 - Elsevier
Lenvatinib, a multi-target tyrosine kinase inhibitor (TKI), is an emerging first-line therapy for
hepatocellular carcinoma (HCC). Its application has changed the status of sorafenib as the …

Hepatocellular carcinoma: molecular mechanism, targeted therapy, and biomarkers

Y Wang, B Deng - Cancer and Metastasis Reviews, 2023 - Springer
Hepatocellular carcinoma (HCC) is a common malignancy and one of the leading causes of
cancer-related death. The biological process of HCC is complex, with multiple factors …

Lenvatinib for hepatocellular carcinoma: a literature review

T Hatanaka, A Naganuma, S Kakizaki - Pharmaceuticals, 2021 - mdpi.com
Lenvatinib, which is an oral multikinase inhibitor, showed non-inferiority to the sorafenib in
terms of overall survival (OS) and a higher objective response rate (ORR) and better …

Objective response by mRECIST to initial lenvatinib therapy is an independent factor contributing to deep response in hepatocellular carcinoma treated with lenvatinib …

H Kuroda, T Oikawa, M Ninomiya, M Fujita, K Abe… - Liver Cancer, 2022 - karger.com
Objective: There is limited information regarding the benefits of Lenvatinib-transcatheter
arterial chemoembolization (LEN-TACE) sequential therapy for unresectable hepatocellular …

Contrast-enhanced ultrasound for monitoring treatment response in different stages of hepatocellular carcinoma

M Faccia, M Garcovich, ME Ainora, L Riccardi… - Cancers, 2022 - mdpi.com
Simple Summary The evaluation of tumor response to anti-cancer therapy is critical in
oncology for the prompt determination of subsequent treatment and follow-up strategies …

Prediction of response to lenvatinib monotherapy for unresectable hepatocellular carcinoma by machine learning radiomics: a multicenter cohort study

Z Bo, B Chen, Z Zhao, Q He, Y Mao, Y Yang, F Yao… - Clinical Cancer …, 2023 - AACR
Purpose: We aimed to construct machine learning (ML) radiomics models to predict
response to lenvatinib monotherapy for unresectable hepatocellular carcinoma (HCC) …

[HTML][HTML] Conversion hepatectomy for hepatocellular carcinoma with main portal vein tumour thrombus after lenvatinib treatment: A case report

K Takahashi, J Kim, A Takahashi… - World Journal of …, 2021 - ncbi.nlm.nih.gov
BACKGROUND Hepatocellular carcinoma (HCC) accompanied by portal vein tumour
thrombus (PVTT) presents an aggressive disease course, worsening liver function reserve …

Conversion hepatectomy for huge hepatocellular carcinoma with arterioportal shunt after chemoembolization and lenvatinib therapy

N Sato, T Beppu, K Kinoshita, H Yuki… - Anticancer …, 2019 - ar.iiarjournals.org
Large tumor size and arterioportal shunt are poor prognostic factors for hepatocellular
carcinoma. Lenvatinib is a novel and potent multi-tyrosine kinase inhibitor developed in …

Favorable radiological antitumor response at 2 weeks after starting lenvatinib for patients with advanced hepatocellular carcinoma

T Kuzuya, M Ishigami, T Ito, Y Ishizu… - hepatology …, 2020 - Wiley Online Library
Aim We aimed to investigate the radiological antitumor response at 2 weeks after starting
lenvatinib for patients with advanced hepatocellular carcinoma in real‐world practice …

Prediction of therapeutic response using contrast-enhanced ultrasound in Japanese patients treated with atezolizumab and bevacizumab for unresectable …

H Takada, K Yamashita, L Osawa, Y Komiyama… - Oncology, 2023 - karger.com
Introduction: Atezolizumab and bevacizumab (AB) therapy was the first-line treatment for
unresectable hepatocellular carcinoma (u-HCC). However, the predictive marker of …