For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …

Cyclooxygenase (COX) enzymes comprise COX-1 and COX-2 isoforms and are responsible
for prostaglandin production. Prostaglandins have critical roles in the inflammation pathway …

Developing novel antimicrobial agents has become a necessitate due to the increasing rate
of microbial resistance to antibiotics. All the newly adamantane derivatives were evaluated …

The ever-increasing environmental pollution and its health concerns appeal replacement of
conventional organic synthesis with green synthetic methodology. This review presented …

Background Pyrazolopyrimidine heterocycle and its isosteres represent the main scaffold for
many pharmacologically active drugs including anti-inflammatory agents. The COX-2 …

The present paper is devoted to the search for drug-like molecules with anticancer
properties using the thiazolo [3, 2-b][1, 2, 4] triazole-6-one scaffold. A series of 24 novel …

Despite the greatest achievement in the development of anti-inflammatory agents in the last
two decades, the current clinical drugs suffer from a variety of complications in community …

Two 3, 6-disubstituted-[1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazole derivatives, namely, 3-
(adamantan-1-yl)-6-(2-chloro-6-fluorophenyl)-[1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazole 1 …

A series of 2, 3-dihydroquinazolin-4 (1 H)-one derivatives (3a–3m) was screened for in vitro
whole-cell antitubercular activity against the tubercular strain H37Rv and multidrug-resistant …

The respiratory infection tuberculosis is caused by the bacteria Mycobacterium tuberculosis
and its unrelenting spread caused millions of deaths around the world. Hence, it is needed …