Alert for an epidemic of oral cancer due to use of the betel quid substitutes gutkha and pan masala: a review of agents and causative mechanisms

U Nair, H Bartsch, J Nair - Mutagenesis, 2004 - academic.oup.com
Abstract In south‐east Asia, Taiwan and Papua New Guinea, smoking, alcohol consumption
and chewing of betel quid with or without tobacco or areca nut with or without tobacco are …

Antimutagens and anticarcinogens: a survey of putative interceptor molecules

PE Hartman, DM Shankel - Environmental and Molecular …, 1990 - Wiley Online Library
In this review recent publications are cited for a number of antimutagens. The molecules
surveyed are potential or proven “desmutagens” or “interceptors.” These are biologically …

Antimalarial Activity of Methanolic Leaf Extract of Piper betle L.

AH Al-Adhroey, ZM Nor, HM Al-Mekhlafi, AA Amran… - Molecules, 2010 - mdpi.com
The need for new compounds active against malaria parasites is made more urgent by the
rapid spread of drug-resistance to available antimalarial drugs. The crude methanol extract …

[PDF][PDF] Piper betel Linn (betel vine), the maligned Southeast Asian medicinal plant possesses cancer preventive effects: Time to reconsider the wronged opinion

MP Rai, KR Thilakchand, PL Palatty, P Rao… - Asian Pac J Cancer …, 2011 - researchgate.net
Abstract Since antiquity, Piper betel Linn (betel vine; family Piperaceae) has been an
important medicinal agent in the various traditional and folk systems of medicine in …

Essential Oil of Betel Leaf (Piper betle L.): A Novel Addition to the World Food Sector

P Guha, S Nandi - Essential Oil Research: Trends in Biosynthesis …, 2019 - Springer
Betel leaf grows on a perennial vine (Piper betle L.). It is consumed in fresh and raw state for
digestive, refreshing, stimulating, aphrodisiac, etc. effects by about two billion people. These …

Inducing the cell cycle arrest and apoptosis of oral KB carcinoma cells by hydroxychavicol: roles of glutathione and reactive oxygen species

MC Chang, BJ Uang, HL Wu, JJ Lee… - British journal of …, 2002 - Wiley Online Library
Hydroxychavicol (HC; 10–50 μm), a betel leaf component, was found to suppress the 2%
H2O2‐induced lucigenin chemiluminescence for 53–75%. HC (0.02–2 μm) was also able to …

[HTML][HTML] Anti-inflammatory and antioxidant activities of methanol extract of Piper betle Linn.(Piper betle L.) leaves and stems by inhibiting NF-κB/MAPK/Nrf2 signaling …

J Seo, U Lee, S Seo, AE Wibowo… - Biomedicine & …, 2022 - Elsevier
Oxidative stress and chronic inflammation are closely linked to various diseases. However,
previous studies have demonstrated that plant extracts could prevent and alleviate these …

The phytochemistry, traditional uses and pharmacology of Piper Betel. linn (Betel Leaf): A pan-asiatic medicinal plant

F Fazal, PP Mane, MP Rai, KR Thilakchand… - Chinese journal of …, 2014 - Springer
Abstract Since antiquity, Piper betel. Linn, commonly known as betel vine, has been used as
a religious, recreational and medicinal plant in Southeast Asia. The leaves, which are the …

Hydroxychavicol, a novel betel leaf component, inhibits platelet aggregation by suppression of cyclooxygenase, thromboxane production and calcium mobilization

MC Chang, BJ Uang, CY Tsai, HL Wu… - British journal of …, 2007 - Wiley Online Library
Background and purpose: Platelet hyperactivity is important in the pathogenesis of
cardiovascular diseases. Betel leaf (PBL) is consumed by 200‐600 million betel quid …

Clastogenic effect for cigarette smoking but not areca quid chewing as measured by micronuclei in exfoliated buccal mucosal cells

PA Wu, CH Loh, LL Hsieh, TY Liu, CJ Chen… - … /Genetic Toxicology and …, 2004 - Elsevier
The objective of this study was to use the micronuclei from exfoliated buccal mucosal cells to
investigate the clastogenic effects of areca quid chewing and cigarette smoking, as well as …