Vascularization is the key challenge in tissue engineering

EC Novosel, C Kleinhans, PJ Kluger - Advanced drug delivery reviews, 2011 - Elsevier
The main limitation in engineering in vitro tissues is the lack of a sufficient blood vessel
system—the vascularization. In vivo almost all tissues are supplied by these endothelial cell …

Vascularization strategies for tissue engineering

M Lovett, K Lee, A Edwards… - Tissue Engineering Part B …, 2009 - liebertpub.com
Tissue engineering is currently limited by the inability to adequately vascularize tissues in
vitro or in vivo. Issues of nutrient perfusion and mass transport limitations, especially oxygen …

Metallic ions as therapeutic agents in tissue engineering scaffolds: an overview of their biological applications and strategies for new developments

V Mourino, JP Cattalini… - Journal of the Royal …, 2012 - royalsocietypublishing.org
This article provides an overview on the application of metallic ions in the fields of
regenerative medicine and tissue engineering, focusing on their therapeutic applications …

[HTML][HTML] 3D bioprinting photo-crosslinkable hydrogels for bone and cartilage repair

Q Mei, J Rao, HP Bei, Y Liu, X Zhao - International journal of …, 2021 - ncbi.nlm.nih.gov
Abstract Three-dimensional (3D) bioprinting has become a promising strategy for bone
manufacturing, with excellent control over geometry and microarchitectures of the scaffolds …

Cell microenvironment engineering and monitoring for tissue engineering and regenerative medicine: the recent advances

J Barthes, H Özçelik, M Hindié… - BioMed research …, 2014 - Wiley Online Library
In tissue engineering and regenerative medicine, the conditions in the immediate vicinity of
the cells have a direct effect on cells' behaviour and subsequently on clinical outcomes …

Controlled drug delivery in tissue engineering

M Biondi, F Ungaro, F Quaglia, PA Netti - Advanced drug delivery reviews, 2008 - Elsevier
The concept of tissue and cell guidance is rapidly evolving as more information regarding
the effect of the microenvironment on cellular function and tissue morphogenesis become …

Biomaterial applications in cardiovascular tissue repair and regeneration

MT Lam, JC Wu - Expert review of cardiovascular therapy, 2012 - Taylor & Francis
Cardiovascular disease physically damages the heart, resulting in loss of cardiac function.
Medications can help alleviate symptoms, but it is more beneficial to treat the root cause by …

Importance of dual delivery systems for bone tissue engineering

M Farokhi, F Mottaghitalab, MA Shokrgozar… - Journal of Controlled …, 2016 - Elsevier
Bone formation is a complex process that requires concerted function of multiple growth
factors. For this, it is essential to design a delivery system with the ability to load multiple …

Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications

T Rajangam, SSA An - International journal of nanomedicine, 2013 - Taylor & Francis
Over the past two decades, many types of natural and synthetic polymer-based micro-and
nanocarriers, with exciting properties and applications, have been developed for application …

Sequential delivery of VEGF, FGF-2 and PDGF from the polymeric system enhance HUVECs angiogenesis in vitro and CAM angiogenesis

Y Bai, L Bai, J Zhou, H Chen, L Zhang - Cellular immunology, 2018 - Elsevier
Angiogenesis is an organized series of events, beginning with vessel destabilization,
followed by endothelial cell re-organization, and ending with vessel maturation. The …