Challenges and opportunities in estimating viral genetic diversity from next-generation sequencing data
Many viruses, including the clinically relevant RNA viruses HIV (human immunodeficiency
virus) and HCV (hepatitis C virus), exist in large populations and display high genetic …
virus) and HCV (hepatitis C virus), exist in large populations and display high genetic …
Overview of direct-acting antiviral drugs and drug resistance of hepatitis C virus
DK Li, RT Chung - Hepatitis C Virus Protocols, 2019 - Springer
The advent of direct-acting antivirals (DAAs) has brought about a sudden renaissance in the
treatment of chronic hepatitis C virus (HCV) infection with SVR rates now routinely> 90 …
treatment of chronic hepatitis C virus (HCV) infection with SVR rates now routinely> 90 …
Virologic response following combined ledipasvir and sofosbuvir administration in patients with HCV genotype 1 and HIV co-infection
A Osinusi, K Townsend, A Kohli, A Nelson, C Seamon… - Jama, 2015 - jamanetwork.com
Importance There is an unmet need for interferon-and ribavirin-free treatment for chronic
hepatitis C virus (HCV) infection in patients co-infected with human immunodeficiency virus …
hepatitis C virus (HCV) infection in patients co-infected with human immunodeficiency virus …
[HTML][HTML] Hepatitis C virus genetic variability and evolution
N Echeverría, G Moratorio, J Cristina… - World journal of …, 2015 - ncbi.nlm.nih.gov
Hepatitis C virus (HCV) has infected over 170 million people worldwide and creates a huge
disease burden due to chronic, progressive liver disease. HCV is a single-stranded, positive …
disease burden due to chronic, progressive liver disease. HCV is a single-stranded, positive …
Next generation sequencing of viral RNA genomes
Background With the advent of Next Generation Sequencing (NGS) technologies, the ability
to generate large amounts of sequence data has revolutionized the genomics field. Most …
to generate large amounts of sequence data has revolutionized the genomics field. Most …
Deep sequencing: becoming a critical tool in clinical virology
ME Quiñones-Mateu, S Avila, G Reyes-Teran… - Journal of clinical …, 2014 - Elsevier
Population (Sanger) sequencing has been the standard method in basic and clinical DNA
sequencing for almost 40 years; however, next-generation (deep) sequencing …
sequencing for almost 40 years; however, next-generation (deep) sequencing …
[HTML][HTML] Update on hepatitis B and C virus diagnosis
Viral hepatitis B and C virus (HBV and HCV) are responsible for the most of chronic liver
disease worldwide and are transmitted by parenteral route, sexual and vertical transmission …
disease worldwide and are transmitted by parenteral route, sexual and vertical transmission …
Next-generation sequencing technologies in diagnostic virology
The data deluge produced by next-generation sequencing (NGS) technologies is an
appealing feature for clinical virologists that are involved in the diagnosis of emerging viral …
appealing feature for clinical virologists that are involved in the diagnosis of emerging viral …
[HTML][HTML] ve-SEQ: Robust, unbiased enrichment for streamlined detection and whole-genome sequencing of HCV and other highly diverse pathogens
The routine availability of high-depth virus sequence data would allow the sensitive
detection of resistance-associated variants that can jeopardize HIV or hepatitis C virus …
detection of resistance-associated variants that can jeopardize HIV or hepatitis C virus …
Genomic analysis of viral outbreaks
S Wohl, SF Schaffner, PC Sabeti - Annual review of virology, 2016 - annualreviews.org
Genomic analysis is a powerful tool for understanding viral disease outbreaks. Sequencing
of viral samples is now easier and cheaper than ever before and can supplement …
of viral samples is now easier and cheaper than ever before and can supplement …