Wilms tumour is the most common renal malignancy of childhood. The disease is curable in
the majority of cases, albeit at considerable cost in terms of late treatment-related effects in …

The spectrum of tumours arising in childhood is fundamentally different from that seen in
adults, and they are known to be divergent from adult malignancies in terms of cellular …

Sarcoma represents a highly heterogeneous group of tumours. We report here the first
unbiased and systematic search for gene fusions combined with unsupervised expression …

The SS18-SSX fusion drives oncogenic transformation in synovial sarcoma by bridging
SS18, a member of the mSWI/SNF (BAF) complex, to Polycomb repressive complex 1 …

Malignant renal tumours represent 5% of childhood cancers and include types with likely
different aetiology: Wilms tumour (WT), rhabdoid renal tumour, kidney sarcomas and renal …

Undifferentiated small round cell sarcomas (SRCSs) of bone and soft tissue comprise a
heterogeneous group of highly aggressive tumours associated with a poor prognosis …

With the advent of next-generation sequencing, an increasing number of novel gene fusions
and other abnormalities have emerged recently in the spectrum of EWSR1-negative small …

BCOR is a gene that encodes for an epigenetic regulator involved in the specification of cell
differentiation and body structure development and takes part in the noncanonical polycomb …

Soft tissue undifferentiated round cell sarcoma (URCS) occurring in infants is a
heterogenous group of tumors, often lacking known genetic abnormalities. On the basis of at …

Synovial sarcoma is an aggressive cancer invariably associated with a chromosomal
translocation involving genes encoding the SWI-SNF complex component SS18 and an SSX …