[HTML][HTML] β-Sitosterol as a promising anticancer agent for chemoprevention and chemotherapy: mechanisms of action and future prospects

H Wang, Z Wang, Z Zhang, J Liu, L Hong - Advances in Nutrition, 2023 - Elsevier
Cancer is one of the primary causes of death worldwide, and its incidence continues to
increase yearly. Despite significant advances in research, the search for effective and …

A review of dietary phytochemicals and their relation to oxidative stress and human diseases

R Guan, Q Van Le, H Yang, D Zhang, H Gu, Y Yang… - Chemosphere, 2021 - Elsevier
Phytochemicals refer to active substances in plant-based diets. Phytochemicals found in for
example fruits, vegetables, grains and seed oils are considered relatively safe for …

DRESIS: the first comprehensive landscape of drug resistance information

X Sun, Y Zhang, H Li, Y Zhou, S Shi… - Nucleic acids …, 2023 - academic.oup.com
Widespread drug resistance has become the key issue in global healthcare. Extensive
efforts have been made to reveal not only diverse diseases experiencing drug resistance …

Recent updates on mechanisms of resistance to 5-fluorouracil and reversal strategies in colon cancer treatment

S Azwar, HF Seow, M Abdullah, M Faisal Jabar… - Biology, 2021 - mdpi.com
Simple Summary Acquired resistance to chemotherapy by cancer cells is the predominant
factor in chemotherapy failure, which ultimately leads to disease progression and death …

Molecular mechanism of β-sitosterol and its derivatives in tumor progression

X Bao, Y Zhang, H Zhang, L Xia - Frontiers in oncology, 2022 - frontiersin.org
β-Sitosterol (SIT), a white powdery organic substance with a molecular formula of C29H50O,
is one of the most abundant naturally occurring phytosterols in plants. With a chemical …

Novel strategies to reverse chemoresistance in colorectal cancer

SC Ma, JQ Zhang, TH Yan, MX Miao, YM Cao… - Cancer …, 2023 - Wiley Online Library
Colorectal cancer (CRC) is a common gastrointestinal malignancy with high morbidity and
fatality. Chemotherapy, as traditional therapy for CRC, has exerted well antitumor effect and …

Review on chemical compositions and biological activities of peanut (Arachis hypogeae L.)

L Mingrou, S Guo, CT Ho, N Bai - Journal of food biochemistry, 2022 - Wiley Online Library
Peanut (Arachis hypogeae L.) is a food resource with great nutritional and health functions.
The present review summarized the nutrients (proteins, lipids, carbohydrates, vitamins, and …

Anticancer activity and other biomedical properties of β‐sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches

S Nandi, A Nag, S Khatua, S Sen… - Phytotherapy …, 2024 - Wiley Online Library
Sterols, including β‐sitosterol, are essential components of cellular membranes in both plant
and animal cells. Despite being a major phytosterol in various plant materials …

[HTML][HTML] β-Sitosterol blocks the LEF-1-mediated Wnt/β-catenin pathway to inhibit proliferation of human colon cancer cells

S Gu, F Liu, X Xie, M Ding, Z Wang, X Xing, T Xiao… - Cellular signalling, 2023 - Elsevier
Objectives This study aimed to investigate the LEF-1-mediated Wnt/β-catenin pathway for its
biological functions and prognostic value in colon cancer (CC). Furthermore, the potential …

Disruption of endoplasmic reticulum and ROS production in human ovarian cancer by campesterol

H Bae, S Park, C Yang, G Song, W Lim - Antioxidants, 2021 - mdpi.com
Phytosterols, which are present in a variety of foods, exhibit various physiological functions
and do not have any side effects. Here, we attempted to identify functional role of …