Blood substitutes and oxygen therapeutics: a review
JS Jahr, NR Guinn, DR Lowery… - Anesthesia & …, 2021 - journals.lww.com
Despite the exhaustive search for an acceptable substitute to erythrocyte transfusion, neither
chemical-based products such as perfluorocarbons nor hemoglobin-based oxygen carriers …
chemical-based products such as perfluorocarbons nor hemoglobin-based oxygen carriers …
The reaction of oxy hemoglobin with nitrite: Mechanism, antioxidant-modulated effect, and implications for blood substitute evaluation
The autocatalytic reaction between nitrite and the oxy form of globins involves free radicals.
For myoglobin (Mb), an initial binding of nitrite to the iron-coordinated oxygen molecule was …
For myoglobin (Mb), an initial binding of nitrite to the iron-coordinated oxygen molecule was …
Protein-based blood substitutes: recent attempts at controlling pro-oxidant reactivity with and beyond hemoglobin
Reviewed here are recent attempts to produce protein-based artificial oxygen carriers
(“blood substitutes”). Most of these involve chemical or physical modifications on …
(“blood substitutes”). Most of these involve chemical or physical modifications on …
Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity
A series of hemoglobin-based oxygen carrier candidates (HBOC), previously noted for their
differences in prooxidative and physiological reactivity, were compared in terms of the …
differences in prooxidative and physiological reactivity, were compared in terms of the …
Hemoglobin–albumin cross-linking with disuccinimidyl suberate (DSS) and/or glutaraldehyde for blood substitutes
F Scurtu, O Zolog, B Iacob… - Artificial Cells …, 2014 - Taylor & Francis
Hemoglobin (Hb) derivatization for blood substitute purposes often involves multi-step
processes including redox reagents such as borohydride and periodate, with possible …
processes including redox reagents such as borohydride and periodate, with possible …
In vivo evaluation of hemerythrin-based oxygen carriers: Similarities with hemoglobin-based counterparts
We have previously proposed the annelid-derived protein, hemerythrin, as a viable
replacement for hemoglobin in the synthesis of semi-synthetic oxygen carriers (“blood …
replacement for hemoglobin in the synthesis of semi-synthetic oxygen carriers (“blood …
Glutaraldehyde‐Polymerized Hemoglobin: In Search of Improved Performance as Oxygen Carrier in Hemorrhage Models
Hemoglobin‐(Hb‐) based oxygen carriers (HBOC) have for several decades been explored
for treatment of hemorrhage. In our previous top‐up tests, HBOC with lower in vitro …
for treatment of hemorrhage. In our previous top‐up tests, HBOC with lower in vitro …
Selective Attachment of Polyethylene Glycol to Hemerythrin for Potential Use in Blood Substitutes
Due to its ability to reversibly bind O2, alongside a relatively low redox reactivity and a
limited cytotoxicity, the oxygen-carrying protein hemerythrin has been considered as an …
limited cytotoxicity, the oxygen-carrying protein hemerythrin has been considered as an …
Artificial red blood cells
K Ferenz, O Karaman, SB Shah - Nanotechnology for Hematology, Blood …, 2022 - Elsevier
To overcome transfusion-associated problems, the development of artificial red blood cells
aims to provide an unlimited source of O 2 supply/CO 2 disposal as ready-to-use with any …
aims to provide an unlimited source of O 2 supply/CO 2 disposal as ready-to-use with any …
Capillary electrophoretic analysis of whole blood samples for hemoglobin‐based oxygen carriers without the use of immunoprecipitation
CR Harrison, S Vydha - Electrophoresis, 2012 - Wiley Online Library
Hemoglobin‐based oxygen carriers (HBOC s) are blood substitutes, synthesized by
polymerizing hemoglobin, which are being developed and investigated as alternatives to …
polymerizing hemoglobin, which are being developed and investigated as alternatives to …