Extracellular vesicles (EVs) are complex lipid membrane vehicles with variable expressions
of molecular cargo, composed of diverse subpopulations that participate in the intercellular …

Cancer is a major medical problem worldwide. Due to its high heterogeneity, the use of the
same drugs or surgical methods in patients with the same tumor may have different curative …

Recent single-cell studies of cancer in both mice and humans have identified the
emergence of a myofibroblast population specifically marked by the highly restricted leucine …

Recent technological advances have enabled massively parallel chromatin profiling with
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …

The role of non-neuronal cells in Alzheimer's disease progression has not been fully
elucidated. Using single-nucleus RNA sequencing, we identified a population of disease …

By engaging angiotensin-converting enzyme 2 (ACE2 or Ace2), the novel pathogenic
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades host cells and …

Adipose tissue is usually classified on the basis of its function as white, brown or beige
(brite). It is an important regulator of systemic metabolism, as shown by the fact that …

While intestinal Th17 cells are critical for maintaining tissue homeostasis, recent studies
have implicated their roles in the development of extra-intestinal autoimmune diseases …

Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq
(scRNA-Seq) profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA …

Single-cell RNA sequencing (scRNA-seq) data are commonly affected by technical artifacts
known as" doublets," which limit cell throughput and lead to spurious biological conclusions …