Capillary forces generated by biomolecular condensates
Liquid–liquid phase separation and related phase transitions have emerged as generic
mechanisms in living cells for the formation of membraneless compartments or biomolecular …
mechanisms in living cells for the formation of membraneless compartments or biomolecular …
Synthetic protein condensates for cellular and metabolic engineering
Protein condensates are distinct structures assembled in living cells that concentrate
molecules via phase separation in a confined subcellular compartment. In the past decade …
molecules via phase separation in a confined subcellular compartment. In the past decade …
Liquid-liquid phase separation of α-synuclein: a new mechanistic insight for α-synuclein aggregation associated with Parkinson's disease pathogenesis
Aberrant aggregation of the misfolded presynaptic protein, α-Synuclein (α-Syn) into Lewy
body (LB) and Lewy neuritis (LN) is a major pathological hallmark of Parkinson's disease …
body (LB) and Lewy neuritis (LN) is a major pathological hallmark of Parkinson's disease …
Condensate interfacial forces reposition DNA loci and probe chromatin viscoelasticity
Biomolecular condensates assemble in living cells through phase separation and related
phase transitions. An underappreciated feature of these dynamic molecular assemblies is …
phase transitions. An underappreciated feature of these dynamic molecular assemblies is …
Biomolecular condensate drives polymerization and bundling of the bacterial tubulin FtsZ to regulate cell division
B Ramm, D Schumacher, A Harms, T Heermann… - Nature …, 2023 - nature.com
Cell division is spatiotemporally precisely regulated, but the underlying mechanisms are
incompletely understood. In the social bacterium Myxococcus xanthus, the …
incompletely understood. In the social bacterium Myxococcus xanthus, the …
Metabolic channeling: predictions, deductions, and evidence
With the elucidation of myriad anabolic and catabolic enzyme-catalyzed cellular pathways
crisscrossing each other, an obvious question arose: how could these networks operate with …
crisscrossing each other, an obvious question arose: how could these networks operate with …
Open questions on liquid–liquid phase separation
E Spruijt - Communications Chemistry, 2023 - nature.com
Liquid-liquid phase separation (LLPS) underlies the formation of intracellular membraneless
compartments in biology and may have played a role in the formation of protocells that …
compartments in biology and may have played a role in the formation of protocells that …
[HTML][HTML] Liquid-to-solid phase transition of oskar ribonucleoprotein granules is essential for their function in Drosophila embryonic development
M Bose, M Lampe, J Mahamid, A Ephrussi - Cell, 2022 - cell.com
Asymmetric localization of oskar ribonucleoprotein (RNP) granules to the oocyte posterior is
crucial for abdominal patterning and germline formation in the Drosophila embryo. We show …
crucial for abdominal patterning and germline formation in the Drosophila embryo. We show …
Putting the squeeze on phase separation
Phase separation is a ubiquitous process and finds applications in a variety of biological,
organic, and inorganic systems. Nature has evolved the ability to control phase separation to …
organic, and inorganic systems. Nature has evolved the ability to control phase separation to …
Non-specific adhesive forces between filaments and membraneless organelles
TJ Böddeker, KA Rosowski, D Berchtold… - Nature physics, 2022 - nature.com
Many membraneless organelles are liquid-like domains that form inside the active,
viscoelastic environment of living cells through phase separation. To investigate the …
viscoelastic environment of living cells through phase separation. To investigate the …