Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

The field of research on cellular senescence experienced a rapid expansion from being
primarily focused on in vitro aspects of aging to the vast territories of animal and clinical …

Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model
organisms and improve human health. The natural polyamine spermidine has been similarly …

Fasting has been practiced for millennia, but, only recently, studies have shed light on its
role in adaptive cellular responses that reduce oxidative damage and inflammation, optimize …

Methionine restriction (MetR) extends lifespan across different species and exerts beneficial
effects on metabolic health and inflammatory responses. In contrast, certain cancer cells …

Dietary restriction (DR) is the most robust environmental manipulation known to increase
active and healthy lifespan in many species. Despite differences in the protocols and the …

Programmed cell death (PCD) pathways, including apoptosis and regulated necrosis, are
required for normal cell turnover and tissue homeostasis. Mis-regulation of PCD is …

Determination of cell viability is the most commonly used method for assessing the impact of
various types of stressors in toxicity research and in industrial microbiology studies. Viability …

The budding yeast Saccharomyces cerevisiae is a powerful model organism for studying
fundamental aspects of eukaryotic cell biology. This Primer article presents a brief historical …

A healthy proteome is essential for cell survival. Protein misfolding is linked to a rapidly
expanding list of human diseases, ranging from neurodegenerative diseases to aging and …