Calmodulin is the primary sensor of intracellular calcium (Ca2+) levels in eukaryotic cells
playing a key role in the proper deciphering of Ca2+ signalling. Given the versatility of Ca2+ …

Voltage-gated calcium channels (CaVs) are large, transmembrane multiprotein complexes
that couple membrane depolarization to cellular calcium entry. These channels are central …

Calmodulin regulation of CaV channels is a prominent Ca2+ feedback mechanism
orchestrating vital adjustments of Ca2+ entry. The long-held structural correlation of this …

Introduction Investigation into the action mechanisms of plant secondary metabolites against
pests is a vital strategy for the development of novel promising biopesticides. Scoparone …

Interactions between voltage‐gated calcium channels (CaVs) and calmodulin (CaM)
modulate CaV function. In this study, we report the structure of a Ca2+/CaM CaV1. 2 C …

Cav1. 2 Ca2+ channels, a type of voltage-gated L-type Ca2+ channel, are ubiquitously
expressed, and the predominant Ca2+ channel type, in working cardiac myocytes. Cav1. 2 …

Long QT syndrome (LQTS) is a human inherited heart condition that can cause life-
threatening arrhythmia including sudden cardiac death. Mutations in the ubiquitous Ca 2+ …

Calmodulin (CaM) is an important signaling molecule that regulates a vast array of cellular
functions by activating second messengers involved in cell function and plasticity. Low …

Rationale: CaV1. 2 channels are essential for excitation–contraction coupling in the
cardiovascular system, and alternative splicing optimizes its role. Galectin-1 (Gal-1) has …

NSCaTE is a short linear motif of (x W xxx (I or L) xxxx), composed of residues with a high
helix-forming propensity within a mostly disordered N-terminus that is conserved in L-type …