Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe

G Kerner, AL Neehus, Q Philippot, J Bohlen, D Rinchai… - Cell genomics, 2023 - cell.com
Ancient genomics can directly detect human genetic adaptation to environmental cues.
However, it remains unclear how pathogens have exerted selective pressures on human …

Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy

J González-Peñas, L De Hoyos, CM Díaz-Caneja… - Scientific Reports, 2023 - nature.com
Schizophrenia is a debilitating psychiatric disorder associated with a reduced fertility and
decreased life expectancy, yet common predisposing variation substantially contributes to …

Neandertal introgression partitions the genetic landscape of neuropsychiatric disorders and associated behavioral phenotypes

M Dannemann, Y Milaneschi, D Yermakovich… - Translational …, 2022 - nature.com
Despite advances in identifying the genetic basis of psychiatric and neurological disorders,
fundamental questions about their evolutionary origins remain elusive. Here, introgressed …

Genome-wide identification of the shared genetic basis of cannabis and cigarette smoking and schizophrenia implicates NCAM1 and neuronal abnormality

W Song, GN Lin, S Yu, M Zhao - Psychiatry Research, 2022 - Elsevier
Objectives Confirming the existence and composition of the shared genetic basis of
Schizophrenia and cannabis and cigarette smoking has critical values for the clinical …

Analysis of Evolutionary Conservation, Expression Level, and Genetic Association at a Genome-wide Scale Reveals Heterogeneity Across Polygenic Phenotypes

AS Giel, J Bigge, J Schumacher, C Maj… - … Biology and Evolution, 2024 - academic.oup.com
Understanding the expression level and evolutionary rate of associated genes with human
polygenic diseases provides crucial insights into their disease-contributing roles. In this …

Assessment of the Genetic Characteristics of a Generation Born during a Long-Term Socioeconomic Crisis

SV Mikhailova, DE Ivanoshchuk, PS Orlov, A Bairqdar… - Genes, 2023 - mdpi.com
Background: A socioeconomic crisis in Russia lasted from 1991 to 1998 and was
accompanied by a sharp drop in the birth rate. The main factor that influenced the refusal to …

[HTML][HTML] The contribution of Neanderthal introgression and natural selection to neurodegenerative diseases

Z Chen, RH Reynolds, AF Pardiñas, SAG Taliun… - Neurobiology of …, 2023 - Elsevier
Humans are thought to be more susceptible to neurodegeneration than equivalently-aged
primates. It is not known whether this vulnerability is specific to anatomically-modern …

Mosaic patterns of selection in genomic regions associated with diverse human traits

A Abraham, AL LaBella, JA Capra, A Rokas - PLoS genetics, 2022 - journals.plos.org
Natural selection shapes the genetic architecture of many human traits. However, the
prevalence of different modes of selection on genomic regions associated with variation in …

Testing for differences in polygenic scores in the presence of confounding

J Blanc, JJ Berg - BioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Polygenic scores have become an important tool in human genetics, enabling the prediction
of individuals' phenotypes from their genotypes. Understanding how the pattern of …

[图书][B] The world behind the world: Consciousness, Free Will, and the Limits of Science

E Hoel - 2024 - books.google.com
From a Forbes 30 Under 30 scientist comes a fascinating exploration into how the brain
creates our conscious experiences—potentially revolutionizing neuroscience and the future …