Insulin-like growth factors (IGFs) play important roles in mammalian growth, development,
aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and …

IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the
cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti …

The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and
development, and when deregulated makes an important contribution to disease. Here, we …

Insulin-like growth factor 1 (IGF1) is a peptide growth factor with important functions in
multiple aspects of growth, development and metabolism. The biological actions of IGF1 are …

The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development
and progression of cancer; however, therapeutics targeting it have had disappointing results …

In this review, we provide an overview of the role of the insulin-like growth factor (IGF)
signaling pathway in breast cancer and discuss its potential as a therapeutic target. The IGF …

IGF-1R inhibitors arrived in the clinic accompanied by optimism based on preclinical activity
of IGF-1R targeting, and recognition that low IGF bioactivity protects from cancer. This was …

Cancer cells frequently exploit the IGF signaling, a fundamental pathway mediating
development, cell growth, and survival. As a consequence, several components of the IGF …

Drug resistance is a primary cause of chemotherapeutic failure; however, how this
resistance develops is complex. A comprehensive understanding of chemotherapeutic …

The insulin-like growth factor (IGF) axis plays important roles in cancer development and
metastasis. The type 1 IGF receptor (IGF-1R) is a key member in the IGF axis and has long …