Is the blood–brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data
The blood–brain barrier (BBB) excludes the vast majority of cancer therapeutics from normal
brain. However, the importance of the BBB in limiting drug delivery and efficacy is …
brain. However, the importance of the BBB in limiting drug delivery and efficacy is …
Radiotherapy for glioblastoma: clinical issues and nanotechnology strategies
R Li, H Wang, Q Liang, L Chen, J Ren - Biomaterials Science, 2022 - pubs.rsc.org
Glioblastoma multiforme (GBM) is the most common primary brain cancer in adults with poor
prognosis. Despite the current state of knowledge on its genetic characteristics, relatively …
prognosis. Despite the current state of knowledge on its genetic characteristics, relatively …
Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
Intratumoral genomic heterogeneity in glioblastoma (GBM) is a barrier to overcoming
therapy resistance. Treatments that are effective independent of genotype are urgently …
therapy resistance. Treatments that are effective independent of genotype are urgently …
Radiation therapy for glioblastoma: executive summary of an American Society for Radiation Oncology evidence-based clinical practice guideline
Purpose To present evidence-based guidelines for radiation therapy in treating glioblastoma
not arising from the brainstem. Methods and materials The American Society for Radiation …
not arising from the brainstem. Methods and materials The American Society for Radiation …
Macrophage exclusion after radiation therapy (MERT): a first in human phase I/II trial using a CXCR4 inhibitor in glioblastoma
Purpose: Preclinical studies have demonstrated that postirradiation tumor revascularization
is dependent on a stromal cell–derived factor-1 (SDF-1)/CXC chemokine receptor type 4 …
is dependent on a stromal cell–derived factor-1 (SDF-1)/CXC chemokine receptor type 4 …
Effect of radiation treatment volume reduction on lymphopenia in patients receiving chemoradiotherapy for glioblastoma
Purpose To evaluate whether reduction in glioblastoma radiation treatment volume can
reduce risk of acute severe lymphopenia (ASL). Methods and Materials A total of 210 …
reduce risk of acute severe lymphopenia (ASL). Methods and Materials A total of 210 …
Radiotherapy in Glioblastoma: the Past, the Present and the Future
The aim of this review is to explore the changing utility of radiotherapy in the treatment of
patients with glioblastoma over the past 60 years. Together with surgery, radiotherapy has …
patients with glioblastoma over the past 60 years. Together with surgery, radiotherapy has …
Classification of progression patterns in glioblastoma: analysis of predictive factors and clinical implications
H Jiang, K Yu, M Li, Y Cui, X Ren, C Yang… - Frontiers in …, 2020 - frontiersin.org
Background This study was designed to explore the progression patterns of IDH-wildtype
glioblastoma (GBM) at first recurrence after chemoradiotherapy. Methods Records from 247 …
glioblastoma (GBM) at first recurrence after chemoradiotherapy. Methods Records from 247 …
The American Brachytherapy Society consensus statement on intraoperative radiation therapy
MC Tom, N Joshi, F Vicini, AJ Chang, TS Hong… - Brachytherapy, 2019 - Elsevier
Purpose Although radiation therapy has traditionally been delivered with external beam or
brachytherapy, intraoperative radiation therapy (IORT) represents an alternative that may …
brachytherapy, intraoperative radiation therapy (IORT) represents an alternative that may …
High grade glioma radiation therapy on a high field 1.5 Tesla MR-Linac-workflow and initial experience with daily adapt-to-position (ATP) MR guidance: A first report
Purpose This study reports the workflow and initial clinical experience of high grade glioma
(HGG) radiotherapy on the 1.5 T MR-Linac (MRL), with a focus on the temporal variations of …
(HGG) radiotherapy on the 1.5 T MR-Linac (MRL), with a focus on the temporal variations of …