Glucagon-like peptide 1 (GLP-1) is a hormone that is encoded in the proglucagon gene. It is
mainly produced in enteroendocrine L cells of the gut and is secreted into the blood stream …

The major goal in the treatment of type 2 diabetes mellitus is to control the hyperglycaemia
characteristic of the disease. However, treatment with common therapies such as insulin or …

We present rna22, a method for identifying microRNA binding sites and their corresponding
heteroduplexes. Rna22 does not rely upon cross-species conservation, is resilient to noise …

The physiological effects of glucagon-like peptide-1 (GLP-1) are of immense interest
because of the potential clinical relevance of this peptide. Produced in intestinal L-cells …

Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia caused
by resistance to insulin action, inadequate insulin secretion, or excessive glucagon …

The appropriate secretion of insulin from pancreatic β-cells is critically important to the
maintenance of energy homeostasis. The β-cells must sense and respond suitably to …

Protein SUMOylation is a critically important posttranslational protein modification that
participates in nearly all aspects of cellular physiology. In the nearly 20 years since its …

Ghrelin and leptin are suggested to regulate energy homeostasis as mutual antagonists on
hypothalamic neurons that regulate feeding behavior. We employed reverse genetics to …

Fine-tuning of insulin secretion from pancreatic β-cells participates in blood glucose
homeostasis. Defects in this process can lead to chronic hyperglycemia and diabetes …

Insulin secretion from pancreatic islet beta cells is acutely regulated by a complex interplay
of metabolic and electrogenic events. The electrogenic mechanism regulating insulin …