Wnt signaling is one of a handful of powerful signaling pathways that play crucial roles in the
animal life by controlling the genetic programs of embryonic development and adult …

The cochlea, a coiled structure located in the ventral region of the inner ear, acts as the
primary structure for the perception of sound. Along the length of the cochlear spiral is the …

Background Understanding the dynamic cellular behaviors and underlying molecular
mechanisms that drive morphogenesis is an ongoing challenge in biology. Live imaging …

Sox2 is a high-mobility transcription factor that is one of the earliest markers of developing
inner ear prosensory domains. In humans, mutations in SOX2 cause sensorineural hearing …

Cranial placodes are specialized regions of the ectoderm, which give rise to various sensory
ganglia and contribute to the pituitary gland and sensory organs of the vertebrate head …

The creation of molecular tools able to unravel in vivo spatiotemporal activation of specific
cell signaling events during cell migration, differentiation and morphogenesis is of great …

The inner ear is one of the most morphologically elaborate tissues in vertebrates, containing
a group of mechanosensitive sensory organs that mediate hearing and balance. These …

The anterior heart field (AHF), which contributes to the outflow tract and right ventricle of the
heart, is defined in part by expression of the LIM homeobox transcription factor Isl-1. The …

The inner ear is a structurally complex vertebrate organ built to encode sound, motion, and
orientation in space. Given its complexity, it is not surprising that inner ear dysfunction is a …

Cranial placodes (which include the adenohypophyseal, olfactory, lens, otic, lateral line,
profundal/trigeminal, and epibranchial placodes) give rise to many sense organs and …