HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation

MA Checkley, BG Luttge, EO Freed - Journal of molecular biology, 2011 - Elsevier
The HIV-1 envelope (Env) glycoproteins play an essential role in the virus replication cycle
by mediating the fusion between viral and cellular membranes during the entry process. The …

The tale of the long tail: the cytoplasmic domain of HIV-1 gp41

TS Postler, RC Desrosiers - Journal of virology, 2013 - Am Soc Microbiol
Envelope glycoproteins (Env) of lentiviruses typically possess unusually long cytoplasmic
domains, often 150 amino acids or longer. It is becoming increasingly clear that these …

Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses

P Chen, W Hübner, MA Spinelli, BK Chen - Journal of virology, 2007 - Am Soc Microbiol
Cell-free human immunodeficiency virus type 1 (HIV-1) can initiate infections, but contact
between infected and uninfected T cells can enhance viral spread through intercellular …

Super-resolution microscopy reveals specific recruitment of HIV-1 envelope proteins to viral assembly sites dependent on the envelope C-terminal tail

W Muranyi, S Malkusch, B Müller, M Heilemann… - PLoS …, 2013 - journals.plos.org
The inner structural Gag proteins and the envelope (Env) glycoproteins of human
immunodeficiency virus (HIV-1) traffic independently to the plasma membrane, where they …

Oregano oil and its principal component, carvacrol, inhibit HIV-1 fusion into target cells

S Mediouni, JA Jablonski, S Tsuda… - Journal of …, 2020 - Am Soc Microbiol
Oregano essential oil has long been known for its health-promoting benefits. Here, we report
its activity against viral replication. Oregano oil was found to specifically inhibit lentiviruses …

Tail-interacting protein TIP47 is a connector between Gag and Env and is required for Env incorporation into HIV-1 virions

S Lopez-Verges, G Camus, G Blot… - Proceedings of the …, 2006 - National Acad Sciences
The presence of the envelope glycoprotein Env in HIV-1 virions is essential for infectivity. To
date, the molecular mechanism by which Env is packaged into virions has been largely …

Biochemical evidence of a role for matrix trimerization in HIV-1 envelope glycoprotein incorporation

PR Tedbury, M Novikova, SD Ablan… - Proceedings of the …, 2016 - National Acad Sciences
The matrix (MA) domain of HIV Gag has important functions in directing the trafficking of Gag
to sites of assembly and mediating the incorporation of the envelope glycoprotein (Env) into …

The role of matrix in HIV-1 envelope glycoprotein incorporation

PR Tedbury, EO Freed - Trends in microbiology, 2014 - cell.com
Incorporation of the viral envelope (Env) glycoprotein is a critical requirement for the
production of infectious HIV-1 particles. It has long been appreciated that the matrix (MA) …

Clustering and mobility of HIV-1 Env at viral assembly sites predict its propensity to induce cell-cell fusion

NH Roy, J Chan, M Lambelé, M Thali - Journal of virology, 2013 - Am Soc Microbiol
ABSTRACT HIV-1 Env mediates virus attachment to and fusion with target cell membranes,
and yet, while Env is still situated at the plasma membrane of the producer cell and before its …

Retromer regulates HIV-1 envelope glycoprotein trafficking and incorporation into virions

E Groppelli, AC Len, LA Granger, C Jolly - PLoS pathogens, 2014 - journals.plos.org
The envelope glycoprotein (Env) of the Human Immunodeficiency Virus Type-1 (HIV-1) is a
critical determinant of viral infectivity, tropism and is the main target for humoral immunity; …