Pharmacological and molecular insight on the cardioprotective role of apigenin

SD Thomas, NK Jha, SK Jha, B Sadek, S Ojha - Nutrients, 2023 - mdpi.com
Apigenin is a naturally occurring dietary flavonoid found abundantly in fruits and vegetables.
It possesses a wide range of biological properties that exert antioxidant, anti-inflammatory …

Apigenin: A current review on its beneficial biological activities

X Zhou, F Wang, R Zhou, X Song… - Journal of Food …, 2017 - Wiley Online Library
Abstract Apigenin, identified as 4′, 5, 7‐trihydroxyflavone, is a natural flavonoid compound
present in a variety of fruits, vegetables, functional foods, and medicinal plants. Many studies …

Apigenin attenuates doxorubicin induced cardiotoxicity via reducing oxidative stress and apoptosis in male rats

MFR Zare, K Rakhshan, N Aboutaleb, F Nikbakht… - Life sciences, 2019 - Elsevier
Aims Doxorubicin, an antibiotic belonging to anthracycline family, has been used for
treatment of malignancies. Cardiotoxicity is the main adverse effect of doxorubicin. Apigenin …

Effects of polyphenols on oxidative stress-mediated injury in cardiomyocytes

R Mattera, M Benvenuto, MG Giganti, I Tresoldi… - Nutrients, 2017 - mdpi.com
Cardiovascular diseases are the main cause of mortality and morbidity in the world.
Hypertension, ischemia/reperfusion, diabetes and anti-cancer drugs contribute to heart …

Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms

Z Mushtaq, NB Sadeer, M Hussain… - … Journal of Food …, 2023 - Taylor & Francis
ABSTRACT Apigenin (4,'5, 7-trihydroxyflavone) is one of the most studied flavonoids with
low toxicity and abundantly present phenolic compound in the plant kingdom. The main …

Anthocyanins in cardioprotection: A path through mitochondria

J Liobikas, K Skemiene, S Trumbeckaite… - Pharmacological …, 2016 - Elsevier
Constantly growing experimental data from in vitro, in vivo and epidemiological studies
show the great potential of anthocyanin-containing fruit and berry extracts or pure individual …

Apigenin attenuates adriamycin‐induced cardiomyocyte apoptosis via the PI3K/AKT/mTOR pathway

W Yu, H Sun, W Zha, W Cui, L Xu… - Evidence‐Based …, 2017 - Wiley Online Library
Treatment with Adriamycin (ADR) is one of the major causes of chemotherapy‐induced
cardiotoxicity and therefore is the principal limiting factor in the effectiveness of …

Adiponectin promotes preadipocyte differentiation via the PPARγ pathway

W Yang, C Yang, J Luo, Y Wei… - Molecular …, 2018 - spandidos-publications.com
According to the results of a preliminary study, it was hypothesized that the effects of
adiponectin (APN) on the improvement of atherosclerosis may be associated with adipocyte …

PPAR γ/Nnat/NF‐κB Axis Involved in Promoting Effects of Adiponectin on Preadipocyte Differentiation

W Yang, W Yuan, X Peng, M Wang… - Mediators of …, 2019 - Wiley Online Library
A previous study has demonstrated that adiponectin (APN) could promote preadipocyte
differentiation, and the present study further explored its mechanism. 3T3‐L1 cells were …

Apigenin suppresses the apoptosis of H9C2 rat cardiomyocytes subjected to myocardial ischemia‑reperfusion injury via upregulation of the PI3K/Akt pathway

Z Zhou, Y Zhang, L Lin, J Zhou - Molecular Medicine …, 2018 - spandidos-publications.com
Apigenin, a flavonoid with multiple physiological and pharmacological activities, is
associated with the prevention of cardiovascular diseases. The present study aimed to …