Normal axon development depends on the action of mechanical forces both generated
within the cytoskeleton and outside the cell, but forces of large magnitude or rate cause …

Several important discoveries in growth cone cell biology were made possible by the use of
growth cones derived from cultured Aplysia bag cell neurons, including the characterization …

Elastomers and composites made thereof have wide applications, eg, in automobile,
aerospace, and civil engineering. Predicting fracture in such materials is crucial for efficient …

The highly branched nervous and vascular systems run along parallel trajectories
throughout the human body. This stereotyped pattern of branching shared by the nervous …

In the developing nervous system, axons are guided to their synaptic targets by motile
structures at the axon tip called growth cones, which reorganize their cytoskeleton in order to …

Microtubules (MTs) nucleated by centrosomes form star-shaped structures referred to as
asters. Aster motility and dynamics is vital for genome stability, cell division, polarization and …

We present a mathematical model of membrane polarization in growth cones. We proceed
by coupling an active transport model of cytosolic proteins along a two-dimensional …

Translational motors that depend on cytoskeletal elements, either actin or tubulin, for their
activity are critical for cellular function in eukaryotes. Microtubule (MT)-dependent motors are …

We formulate and analyze three spatio-temporal models for cell polarization in budding
yeast, fission yeast, and the neuronal growth cone, respectively. We focus on the roles of …