Plant molecular farming: A viable platform for recombinant biopharmaceutical production

B Shanmugaraj, CJ I. Bulaon, W Phoolcharoen - Plants, 2020 - mdpi.com
The demand for recombinant proteins in terms of quality, quantity, and diversity is increasing
steadily, which is attracting global attention for the development of new recombinant protein …

Molecular farming–the slope of enlightenment

R Fischer, JF Buyel - Biotechnology advances, 2020 - Elsevier
Molecular farming can be defined as the use of plants to produce recombinant protein
products. The technology is now> 30 years old. The early promise of molecular farming was …

Plants as sources of natural and recombinant anti-cancer agents

JF Buyel - Biotechnology advances, 2018 - Elsevier
Herbal remedies were the first medicines used by humans due to the many
pharmacologically active secondary metabolites produced by plants. Some of these …

Plant cell cultures: biofactories for the production of bioactive compounds

VA Bapat, PB Kavi Kishor, N Jalaja, SM Jain, S Penna - Agronomy, 2023 - mdpi.com
Plants have long been exploited as a sustainable source of food, flavors, agrochemicals,
colors, therapeutic proteins, bioactive compounds, and stem cell production. However, plant …

CRISPR/Cas9‐mediated knockout of six glycosyltransferase genes in Nicotiana benthamiana for the production of recombinant proteins lacking β‐1,2‐xylose and …

J Jansing, M Sack, SM Augustine… - Plant Biotechnology …, 2019 - Wiley Online Library
Plants offer fast, flexible and easily scalable alternative platforms for the production of
pharmaceutical proteins, but differences between plant and mammalian N‐linked glycans …

The potential for microalgae as bioreactors to produce pharmaceuticals

N Yan, C Fan, Y Chen, Z Hu - International journal of molecular sciences, 2016 - mdpi.com
As photosynthetic organisms, microalgae can efficiently convert solar energy into biomass.
Microalgae are currently used as an important source of valuable natural biologically active …

The emerging role of nanotechnology in plant genetic engineering

HJ Squire, S Tomatz, E Voke… - Nature Reviews …, 2023 - nature.com
Genetic engineering to improve the capabilities of plants is essential given climate change
and population growth pressures. Current manipulation methods are laborious and species …

CRISPR screens in plants: approaches, guidelines, and future prospects

C Gaillochet, W Develtere, TB Jacobs - The Plant Cell, 2021 - academic.oup.com
Clustered regularly interspaced short palindromic repeat (CRISPR)-associated systems
have revolutionized genome engineering by facilitating a wide range of targeted DNA …

Inactivation of the β(1,2)-xylosyltransferase and the α(1,3)-fucosyltransferase genes in Nicotiana tabacum BY-2 Cells by a Multiplex CRISPR/Cas9 Strategy Results in …

S Mercx, N Smargiasso, F Chaumont… - Frontiers in plant …, 2017 - frontiersin.org
Plants or plant cells can be used to produce pharmacological glycoproteins such as
antibodies or vaccines. However these proteins carry N-glycans with plant-typical residues …

Biotechnological insights on the expression and production of antimicrobial peptides in plants

B Shanmugaraj, CJI Bulaon, A Malla, W Phoolcharoen - Molecules, 2021 - mdpi.com
The emergence of drug-resistant pathogens poses a serious critical threat to global public
health and requires immediate action. Antimicrobial peptides (AMPs) are a class of short …