Functional pancreatic islet beta cells are essential to ensure glucose homeostasis across
species from zebrafish to humans. These cells show significant heterogeneity, and emerging …

Excessive adiposity in obesity is a significant risk factor for development of type 2 diabetes
(T2D), nonalcoholic fatty liver disease, and other cardiometabolic diseases. An unhealthy …

Coordination of cellular activity through Ca2+ enables β cells to secrete precise quantities of
insulin. To explore how the Ca2+ response is orchestrated in space and time, we implement …

The development of pancreatic islet endocrine cells is a tightly regulated process leading to
the generation of distinct cell types harbouring different hormones in response to small …

Selenium is an essential micronutrient required for the synthesis and function of
selenoproteins, most of which are enzymes involved in maintaining oxidative balance in the …

Type 1 diabetes treatment stands at a crucial and exciting crossroad since the 2022 US
Food and Drug Administration approval of teplizumab to delay disease development. In this …

Obesity-induced β cell dysfunction contributes to the onset of type 2 diabetes. Nevertheless,
elucidating epigenetic mechanisms underlying islet dysfunction at single cell level remains …

This review examines the complexities of Type 2 Diabetes Mellitus (T2DM), focusing on the
critical role of integrating omics technologies with traditional experimental methods. It …

Pancreatic regeneration is a complex process observed in both normal and pathological
conditions. The aim of this review is to provide a comprehensive understanding of the …

Type 1 Diabetes (T1D) is a chronic metabolic disease resulting from insulin deficiency due
to autoimmune loss of pancreatic β cells. In addition to β cell destruction, it is now accepted …