Many cancers possess an incorrect number of chromosomes, a state described as
aneuploidy. Aneuploidy is often caused by Chromosomal Instability (CIN), a process of …

The adipocyte-released hormone-like cytokine/adipokine leptin behaves differently in
obesity compared to its functions in the normal healthy state. In obese individuals, elevated …

All types of cancer cells are addicted to methionine, which is known as the Hoffman effect.
Restricting methionine inhibits the growth and proliferation of all tested types of cancer cells …

Background/Aim: Methionine addiction is a general and fundamental hallmark of cancer.
Methionine addiction can be targeted by methionine restriction (MR). Our laboratory has …

When discussing chromosomal instability, most of the literature focuses on the
characterization of individual molecular mechanisms. These studies search for genomic and …

Receptor tyrosine kinase (RTK) anaplastic lymphoma kinase (ALK) serves a crucial role in
brain development. ALK is located on the short arm of chromosome 2 (2p23) and exchange …

Chromosomal instability (CIN) and aneuploidy are similar concepts but not synonymous.
CIN is the process that leads to chromosome copy number alterations, and aneuploidy is the …

While the importance of chromosomal/nuclear variations vs. gene mutations in diseases is
becoming more appreciated, less is known about its genomic basis. Traditionally …

Background In the past 15 years, impressive progress has been made to understand the
molecular mechanism behind aneuploidy, largely due to the effort of using various-omics …

Drug resistance represents an ultimate challenge for cancer treatment. The initial rationale
behind using chemo-treatment was the preferred elimination of fast-growing cancer cells …