This article reviews the anatomical connections of the paraventricular nucleus of the
thalamus (PVT) and discusses some of the connections by which the PVT could influence …

The hypothalamus is among the most phylogenetically conserved regions in the vertebrate
brain, reflecting its critical role in maintaining physiological and behavioural homeostasis. By …

Lateral hypothalamus (LH) neurons containing the neuropeptide hypocretin (HCRT; orexin)
modulate affective components of arousal, but their relevant synaptic inputs remain poorly …

Background The high prevalence and burden to society of drug abuse and addiction is
undisputed. However, its conceptualisation as a brain disease is controversial, and …

One decade ago, our laboratory provided the first direct evidence linking orexin/hypocretin
signaling with drug seeking by showing that activation of these neurons promotes …

The lateral hypothalamus (LH) is a functionally and anatomically complex brain region that
is involved in the regulation of many behavioral and physiological processes including …

Insomnia disorder is considered as a stress‐related disorder associated with hyperarousal,
stress and emotion dysregulation and the instability of the 'flip‐flop'switch system. The …

In the brain, long-term memories correspond to changes in synaptic weights after certain
patterns of neural activity. Behaviourally, this corresponds to a change in action evoked by a …

Orexins are neuropeptides that are exclusively produced by hypothalamic neurons, which
project throughout the entire brain. Orexin, also known as hypocretins, were initially …

Hypothalamic neuropeptide orexin has been implicated in the pathophysiology of
psychiatric disorders and accumulating clinical evidence indicates a potential link between …