Introduction Most guidelines for IBD still recommend step-by-step therapy with initially
classic drugs such aminosalicylates (in ulcerative colitis) or steroids but avoid prioritizing …

Background The aim of this systematic review and meta-analysis is to assess the efficacy
and safety of faecal microbiota transplantation [FMT] in the treatment of chronic pouchitis …

Objective The main objective of this document is to complete the guidelines already in force
to include new information, particularly regarding new medicines which have been …

Up to 30% of patients with ulcerative colitis (UC) will require a colectomy. Current guidelines
recommend to perform an ileal pouch-anal anastomosis (IPAA) as restorative surgery …

Background NAFLD clinical trials have shown suboptimal results, particularly for liver
fibrosis, despite the robust preclinical drug development. We aimed to assess the …

Chronic pouchitis (CP) occurs in approximately 20% of patients with ulcerative colitis after
total proctocolectomy with ileal pouch anal anastomosis and is categorized as antibiotic …

Background: The application of vedolizumab (VDZ) subcutaneous (SC) formulation has
brought more convenience and hope to patients with moderate-to-severe inflammatory …

Methods Biomedical databases and the Cochrane Central registry were searched between
1978 and 2021 for randomised controlled trials examining treatment for acute, chronic and …

Background Much of our understanding about the natural history of pouch-related disorders
has been generated from selected populations. We designed a geographically diverse …

Abstract Background and Aims Data regarding the effectiveness and safety of Janus kinase
[JAK] inhibitors and sphingosine-1-phosphate [S1P] receptor modulators in antibiotic …