The eukaryotic cell is compartmentalized into subcellular niches, including membrane-
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …

In the past decade, relative proteomic quantification using isobaric labeling technology has
developed into a key tool for comparing the expression of proteins in biological samples …

Multisystem inflammatory syndrome in children (MIS-C) occurs during or recently following
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and is …

Dissection of complex biological systems requires target-specific control of the function or
abundance of proteins. Genetic perturbations are limited by off-target effects …

Single-cell technologies have described heterogeneity across tissues, but the spatial
distribution and forces that drive single-cell phenotypes have not been well defined …

Comprehensive mass spectrometry (MS)-based proteomics is now feasible, but
reproducible quantification remains challenging, especially for post-translational …

Sleep and wake have global effects on brain physiology, from molecular changes,,–and
neuronal activities to synaptic plasticity,,,–. Sleep–wake homeostasis is maintained by the …

Protein phosphorylation is a post-translational modification (PTM) that orchestrates a diverse
array of cellular processes. Because this modification serves as a rapid and reversible …

Background: Sevoflurane anesthesia induces Tau phosphorylation and cognitive
impairment in neonatal but not in adult mice. Here we tested the hypothesis that differences …

It is being increasingly appreciated that the immunomodulatory functions of PARP1
inhibitors (PARPi) underlie their clinical activities in various BRCA-mutated tumors. PARPi …