Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Tissue repair and fibrosis, an abnormal form of repair, occur in most human organs in
response to injury or inflammation. Fibroblasts play a major role in the normal repair process …

In this comprehensive review, we will dissect the impact of research on proteoglycans
focusing on recent developments involved in their synthesis, degradation, and interactions …

Decorin is a stromal-derived prototype member of the small leucine-rich proteoglycan gene
family. In addition to its functions as a regulator of collagen fibrillogenesis and TGF-β activity …

Atherothrombosis, a multifactorial and multistep artery disorder, represents one of the main
causes of morbidity and mortality worldwide. The development and progression of …

Soluble biglycan, a small leucine-rich proteoglycan, plays a significant role in several
pathologies as it has emerged as an extracellular matrix-derived danger-associated …

In recent years, extensive research has uncovered crucial regulatory roles for the
extracellular matrix (ECM) in regulating autophagy. Autophagy is a ubiquitous and highly …

Proteoglycans and selected extracellular matrix constituents are emerging as intrinsic and
critical regulators of evolutionarily conversed, intracellular catabolic pathways. Often, these …

The tumor stroma of most solid malignancies is characterized by a pathological
accumulation of pro-angiogenic and pro-tumorigenic hyaluronan driving tumorigenesis and …

Antiangiogenic therapy is an established method for the treatment of several cancers and
vascular‐related diseases. Most of the agents employed target the vascular endothelial …