Chemokines play crucial roles in combating microbial infection and initiating tissue repair by
recruiting neutrophils in a timely and coordinated manner. In humans, no less than seven …

Recruitment of leucocytes such as neutrophils to the extravascular space is a critical step of
the inflammation process and plays a major role in the development of various diseases …

Abstract Background Recent Genome Wide Association Studies (GWAS) have identified
novel rare coding variants in immune genes associated with late onset Alzheimer's disease …

Extracellular vesicles (EVs) are lipid bilayer nanovesicles secreted from almost all cells
including cancer. Cancer-derived EVs contribute to cancer progression and malignancy via …

Respiratory diseases, always being a threat towards the health of people all over the world,
are most tightly associated with immune system. Neutrophils serve as an important …

Protein kinase D is a family of evolutionarily conserved serine/threonine kinases that
belongs to the Ca++/Calmodulin-dependent kinase superfamily. Signal transduction …

Human genetic studies have linked rare coding variants in microglial genes, such as
TREM2, and more recently PLCG2 to Alzheimer's disease (AD) pathology. The P522R …

Apart from bacterial formyl peptides or viral chemokine mimicry, a non-vertebrate or insect
protein that directly attracts mammalian innate cells such as neutrophils has not been …

How phagocytes find invading microorganisms and eliminate pathogenic ones from human
bodies is a fundamental question in the study of infectious diseases. About 2.5 billion years …

Leukocyte chemoattractant receptors are members of the G-protein coupled receptor
(GPCR) family. Signaling downstream of these receptors directs the localization, positioning …