Targeting galectin-driven regulatory circuits in cancer and fibrosis
Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a
broad range of physiological and pathological processes. As a group, these proteins use …
broad range of physiological and pathological processes. As a group, these proteins use …
Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection
The immune system is coordinated by an intricate network of stimulatory and inhibitory
circuits that regulate host responses against endogenous and exogenous insults. Disruption …
circuits that regulate host responses against endogenous and exogenous insults. Disruption …
Glycomimetics for the inhibition and modulation of lectins
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
Covid‐19 and oral diseases: Crosstalk, synergy or association?
DA Brandini, AS Takamiya, P Thakkar… - Reviews in medical …, 2021 - Wiley Online Library
Summary The coronavirus disease 2019 (Covid‐19) is a viral infection caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) that clinically affects multiple …
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) that clinically affects multiple …
Hematopoietic-derived galectin-3 causes cellular and systemic insulin resistance
In obesity, macrophages and other immune cells accumulate in insulin target tissues,
promoting a chronic inflammatory state and insulin resistance. Galectin-3 (Gal3), a lectin …
promoting a chronic inflammatory state and insulin resistance. Galectin-3 (Gal3), a lectin …
CA 19-9: biochemical and clinical aspects
Abstract CA19-9 (carbohydrate antigen 19-9, also called cancer antigen 19-9 or sialylated
Lewis a antigen) is the most commonly used and best validated serum tumor marker for …
Lewis a antigen) is the most commonly used and best validated serum tumor marker for …
Galectin-9 as a biomarker of disease severity
Abstract Galectin-9 (Gal-9) is a β-galactoside binding lectin known for its immunomodulatory
role in various microbial infections. Gal-9 is expressed in all organ systems and localized in …
role in various microbial infections. Gal-9 is expressed in all organ systems and localized in …
Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells
The β-galactoside-binding protein galectin-9 is critical in regulating the immune response,
but the mechanism by which it functions remains unclear. We have demonstrated that …
but the mechanism by which it functions remains unclear. We have demonstrated that …
Galectins and immune responses—just how do they do those things they do?
S Thiemann, LG Baum - Annual review of immunology, 2016 - annualreviews.org
Galectins are a family of mammalian carbohydrate-binding proteins expressed by many cell
types. Galectins can function intracellularly and can also be secreted to bind to cell surface …
types. Galectins can function intracellularly and can also be secreted to bind to cell surface …
Analysis of galectin‐3 levels as a source of coronary heart disease risk during periodontitis
Abstract Background and Objective Different evidence has shown that Galectins have a key
role as modulators of cell surface functions and signaling in a wide range of inflammatory …
role as modulators of cell surface functions and signaling in a wide range of inflammatory …