Innate immune evasion strategies of SARS-CoV-2

JM Minkoff, B tenOever - Nature Reviews Microbiology, 2023 - nature.com
Abstract SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has been
associated with substantial global morbidity and mortality. Despite a tropism that is largely …

[HTML][HTML] From rare disorders of immunity to common determinants of infection: Following the mechanistic thread

JL Casanova, L Abel - Cell, 2022 - cell.com
The immense interindividual clinical variability during any infection is a long-standing
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …

Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia

Q Zhang, D Matuozzo, J Le Pen, D Lee… - Journal of Experimental …, 2022 - rupress.org
Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical
COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in …

Autoantibodies against type I IFNs in patients with critical influenza pneumonia

Q Zhang, A Pizzorno, L Miorin, P Bastard… - Journal of Experimental …, 2022 - rupress.org
Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19
pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring …

Interfering with interferons: A critical mechanism for critical COVID-19 pneumonia

HC Su, H Jing, Y Zhang… - Annual Review of …, 2023 - annualreviews.org
Infection with SARS-CoV-2 results in clinical outcomes ranging from silent or benign
infection in most individuals to critical pneumonia and death in a few. Genetic studies in …

[HTML][HTML] COVID-19, post-acute COVID-19 syndrome (PACS,“long COVID”) and post-COVID-19 vaccination syndrome (PCVS,“post-COVIDvac-syndrome”): Similarities …

F Scholkmann, CA May - Pathology-Research and Practice, 2023 - Elsevier
Worldwide there have been over 760 million confirmed coronavirus disease 2019 (COVID-
19) cases, and over 13 billion COVID-19 vaccine doses have been administered as of April …

Dissecting human population variation in single-cell responses to SARS-CoV-2

Y Aquino, A Bisiaux, Z Li, M O'Neill, J Mendoza-Revilla… - Nature, 2023 - nature.com
Humans display substantial interindividual clinical variability after SARS-CoV-2 infection,–,
the genetic and immunological basis of which has begun to be deciphered. However, the …

PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection

D Xu, W Jiang, L Wu, RG Gaudet, ES Park, M Su… - Nature, 2023 - nature.com
Understanding protective immunity to COVID-19 facilitates preparedness for future
pandemics and combats new SARS-CoV-2 variants emerging in the human population …

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs

P Bastard, SE Vazquez, J Liu, MT Laurie… - Science …, 2023 - science.org
Life-threatening “breakthrough” cases of critical COVID-19 are attributed to poor or waning
antibody (Ab) response to SARS-CoV-2 vaccines in individuals already at risk. Preexisting …

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

T Le Voyer, AV Parent, X Liu, A Cederholm, A Gervais… - Nature, 2023 - nature.com
Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by
autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I …