Apicomplexan parasites rely on calcium-mediated signaling for a variety of vital functions
including protein secretion, motility, cell invasion, and differentiation. These functions are …

Introduction 3. Structure and formation of the DV 4. Hemoglobin digestion 5. Ion
homeostasis 5.1. pH homeostasis 5.2. Calcium homeostasis 6. Transporters in the DV …

Malaria parasites, Plasmodia, spend most of their asexual life cycle within red blood cells,
where they proliferate and mature. The erythrocyte cytoplasm has very low [Ca2+](< 100 …

The phylum Apicomplexa comprises a large group of early branching eukaryotes that
includes a number of human and animal parasites. Calcium controls a number of vital …

The host hormone melatonin increases cytoplasmic Ca2+ concentration and synchronizes
Plasmodium cell cycle (Hotta, CT, ML Gazarini, FH Beraldo, FP Varotti, C. Lopes, RP …

IP 3-dependent Ca 2+ signaling controls a myriad of cellular processes in higher eukaryotes
and similar signaling pathways are evolutionarily conserved in Plasmodium, the intracellular …

The sarco/endoplasmic reticulum calcium ATPase (SERCA), which plays a key role in the
maintenance of Ca2+ ion homeostasis, is an extensively studied enzyme, the inhibition of …

Discovering the mechanisms by which cell signaling controls the cell cycle of the human
malaria parasite Plasmodium falciparum is fundamental to designing more effective …

More than 40% of the World population is at risk of contracting malaria, which affects
primarily poor populations in tropical and subtropical areas. Antimalarial pharmacotherapy …

The acidic food vacuole exerts several important functions during intraerythrocytic
development of the human malarial parasite Plasmodium falciparum. Hemoglobin taken up …