Wnt signaling plays a central regulatory role across a remarkably diverse range of functions
during embryonic development, including those involved in the formation of bone and …

Significance: Chronic wounds are a prevalent and costly problem in the United States.
Improved treatments are needed to heal these wounds and prevent serious complications …

Hereditary mixed polyposis syndrome (HMPS) is characterized by the development of mixed-
morphology colorectal tumors and is caused by a 40-kb genetic duplication that results in …

Wnt plays important role during development and in various diseases. Because Wnts are
lipidated and highly hydrophobic, they can only be purified in the presence of detergents …

Stem cells residing in the periodontal ligament (PDL) support the homeostasis of the
periodontium, but their in vivo identity, source (s), and function (s) remain poorly understood …

WNT morphogens trigger signaling pathways fundamental for embryogenesis, regeneration,
and cancer. WNTs are modified with palmitoleate, which is critical for binding Frizzled (FZD) …

Both the incidence and prevalence of inflammatory bowel disease (IBD) is increasing
globally; in the industrialized world up to 0.5% of the population are affected and around 4.2 …

Adult bone regeneration is orchestrated by the precise actions of osteoprogenitor cells
(OPCs). However, the mechanisms by which OPC proliferation and differentiation are linked …

Wnt proteins are lipid‐modified, short‐range signals that control stem cell self‐renewal and
tissue regeneration. We identified a population of Wnt responsive cells in the pulp cavity …

Wnt signalling proteins are essential for culture of human organ stem cells in organoids, but
most Wnt protein formulations are poorly active in serum-free media. Here we show that …