Single-cell atlas of penile cancer reveals TP53 mutations as a driver of an aggressive phenotype, irrespective of human papillomavirus status, and provides clues for …

L Elst, G Philips, K Vandermaesen, A Bassez, F Lodi… - European Urology, 2024 - Elsevier
Background and objective TP53 loss-of-function (TP53LOF) mutations might be a driver of
poor prognosis and chemoresistance in both human papillomavirus (HPV)-independent …

Biogeographical Impacts of Dental, Oral, and Craniofacial Microbial Reservoirs

QT Easter, BF Matuck, BM Warner… - Journal of Dental …, 2023 - journals.sagepub.com
The human mouth, or oral cavity, is at the crossroads of our external and internal
environments, and it is increasingly evident that local colonization of dental, oral, and …

Multiomic analysis of cervical squamous cell carcinoma identifies cellular ecosystems with biological and clinical relevance

J Fan, F Lu, T Qin, W Peng, X Zhuang, Y Li, X Hou… - Nature …, 2023 - nature.com
Cervical squamous cell carcinoma (CSCC) exhibits a limited response to immune-
checkpoint blockade. Here we conducted a multiomic analysis encompassing single-cell …

[HTML][HTML] New perspectives on biology, disease progression, and therapy response of head and neck cancer gained from single cell RNA sequencing and spatial …

G Heller, T Fuereder, AM Grandits, R Wieser - Oncology Research, 2024 - ncbi.nlm.nih.gov
Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent cancers
worldwide. The main risk factors are consumption of tobacco products and alcohol, as well …

Structure and transcription of integrated HPV DNA in vulvar carcinomas

A Van Arsdale, L Turker, YC Chang, J Gould… - npj Genomic …, 2024 - nature.com
HPV infections are associated with a fraction of vulvar cancers. Through hybridization
capture and DNA sequencing, HPV DNA was detected in five of thirteen vulvar cancers …

[HTML][HTML] Optimized protocol for 3D epithelial cultures supporting human papillomavirus replication

M Laganà, GC Margolles, A Jaracz-Ros… - STAR protocols, 2024 - Elsevier
Human papillomaviruses (HPVs) are commensal viruses with pathogenic potential. Their life
cycle requires the proliferation and differentiation of keratinocytes (KCs) to form pluristratified …

Beyond vaccination: prognostic value of p16-HPV testing in squamous cell cervical cancer

Z Dahbi - Future Virology, 2023 - Future Medicine
Human papillomaviruses (HPVs) are widespread viruses that affect both men and women.
They infect the skin and mucous membranes, most commonly in the intimate areas and …