Obesity is a chronic illness associated with several metabolic derangements and
comorbidities (ie, insulin resistance, leptin resistance, diabetes, etc.) and often leads to …

The hypothalamic control of prolactin secretion is different from other anterior pituitary
hormones, in that it is predominantly inhibitory, by means of dopamine from the …

The gonadotropin-releasing hormone (GnRH) pulse is fundamental for mammalian
reproduction: GnRH pulse regimens are needed as therapies for infertile women as …

In the past decade since kisspeptin/neurokinin B/dynorphin (KNDy) cells were first identified
in the mammalian hypothalamus, a plethora of new research has emerged adding insights …

Kisspeptin (Kiss1) and neurokinin B (NKB) neurocircuits are essential for pubertal
development and fertility. Kisspeptin neurons in the hypothalamic arcuate nucleus …

Childhood obesity, especially in girls, is frequently bound to earlier puberty, which is linked
to higher disease burden later in life. The mechanisms underlying this association remain …

The hormone leptin modulates a diverse range of biological functions, including energy
homeostasis and reproduction. Leptin promotes GnRH function via an indirect action on …

A hypothalamic pulse generator located in the arcuate nucleus controls episodic release of
gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) and is essential for …

Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy)
neurons in the arcuate nucleus play a key role in GnRH pulse generation, with kisspeptin …

Increasing evidence accumulated during the past two decades has demonstrated that the
then-novel kisspeptin, which was discovered in 2001, the known neuropeptides neurokinin …