Cell culture has become an indispensable tool to help uncover fundamental biophysical and
biomolecular mechanisms by which cells assemble into tissues and organs, how these …

Biointerfaces mediate safe and efficient cell manipulation, which is essential for biomedical
innovations in advanced therapies and diagnostics. The biointerface established by vertical …

In vitro tumor models have provided important tools for cancer research and serve as low-
cost screening platforms for drug therapies; however, cancer recurrence remains largely …

Although the biological functions of cell and tissue can be regulated by biochemical factors
(eg, growth factors, hormones), the biophysical effects of materials on the regulation of …

Control of the structure and function of three-dimensional multicellular tissues depends
critically on the spatial and temporal coordination of cellular physical properties, yet the …

Cell adhesion is essential in cell communication and regulation, and is of fundamental
importance in the development and maintenance of tissues. The mechanical interactions …

The tumor microenvironment is a dynamic landscape in which the physical and mechanical
properties evolve dramatically throughout cancer progression. These changes are driven by …

Tissue, cell, and nucleus morphology change during tumor progression. In 2D confluent cell
cultures, different tissue states, such as fluid (unjammed) and solid (jammed), are correlated …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Forces generated by cells are critical regulators of cell adhesion, signaling, and function,
and they are also essential drivers in the morphogenetic events of development. Over the …