NSAIDs: Old acquaintance in the pipeline for cancer treatment and prevention─ Structural modulation, mechanisms of action, and bright future

S Ramos-Inza, AC Ruberte, C Sanmartin… - Journal of Medicinal …, 2021 - ACS Publications
The limitations of current chemotherapeutic drugs are still a major issue in cancer treatment.
Thus, targeted multimodal therapeutic approaches need to be strategically developed to …

Organoselenium compounds in medicinal chemistry

C Gallo‐Rodriguez, JB Rodriguez - ChemMedChem, 2024 - Wiley Online Library
The chemical and biological interest in this element and the molecules bearing selenium
has been exponentially growing over the years. Selenium, formerly designated as a toxin …

[HTML][HTML] Design, synthesis and anticancer evaluation of novel Se-NSAID hybrid molecules: Identification of a Se-indomethacin analog as a potential therapeutic for …

S Ramos-Inza, I Encío, A Raza, AK Sharma… - European journal of …, 2022 - Elsevier
A total of twenty-five novel carboxylic acid, methylester, methylamide or cyano nonsteroidal
anti-inflammatory drug (NSAID) derivatives incorporating Se in the chemical form of …

Therapeutic benefits of selenium in hematological malignancies

MA Ehudin, U Golla, D Trivedi, SD Potlakayala… - International journal of …, 2022 - mdpi.com
Supplementing chemotherapy and radiotherapy with selenium has been shown to have
benefits against various cancers. This approach has also been shown to alleviate the side …

First generation of antioxidant precursors for bioisosteric Se-NSAIDs: Design, synthesis, and in vitro and in vivo anticancer evaluation

S Ramos-Inza, C Aliaga, I Encío, A Raza, AK Sharma… - Antioxidants, 2023 - mdpi.com
The introduction of selenium (Se) into organic scaffolds has been demonstrated to be a
promising framework in the field of medicinal chemistry. A novel design of nonsteroidal anti …

Unveiling a new selenocyanate as a multitarget candidate with anticancer, antileishmanial and antibacterial potential

S Ramos-Inza, A Henriquez-Figuereo, E Moreno… - Molecules, 2022 - mdpi.com
Currently, cancer, leishmaniasis and bacterial infections represent a serious public health
burden worldwide. Six cinnamyl and benzodioxyl derivatives incorporating selenium (Se) as …

Trace elements in pancreatic cancer

Y Yanjun, Z Jing, S Yifei, G Gangzhao… - Cancer …, 2024 - Wiley Online Library
Background Pancreatic cancer (PCA) is an extremely aggressive malignant cancer with an
increasing incidence and a low five‐year survival rate. The main reason for this high …

[HTML][HTML] Following the Trace of Cyclodextrins on the Selenium and Tellurium Odyssey

C Morán-Serradilla, D Plano, AK Sharma… - International journal of …, 2024 - mdpi.com
There is an urgent need to develop safer and more effective modalities for the treatment of
numerous pathologies due to the increasing rates of drug resistance, undesired side effects …

Selenization of Small Molecule Drugs: A New Player on the Board

C Morán-Serradilla, D Plano, C Sanmartín… - Journal of Medicinal …, 2024 - ACS Publications
There is an urgent need to develop safer and more effective modalities for the treatment of a
wide range of pathologies due to the increasing rates of drug resistance, undesired side …

Seleno‐aspirin compound AS‐10 promotes histone acetylation ahead of suppressing androgen receptor transcription, G1 arrest, and apoptosis of prostate cancer …

DN Karelia, S Kim, D Plano, AK Sharma, C Jiang… - The …, 2023 - Wiley Online Library
Background The novel selenium‐aspirin compound AS‐10 was recently reported by us with
a cancer cell killing potency three orders of magnitude greater than aspirin in pancreatic …