Cannabinoids as key regulators of inflammasome signaling: a current perspective

SV Suryavanshi, I Kovalchuk, O Kovalchuk - Frontiers in immunology, 2021 - frontiersin.org
Inflammasomes are cytoplasmic inflammatory signaling protein complexes that detect
microbial materials, sterile inflammatory insults, and certain host-derived elements …

The treatment of cognitive, behavioural and motor impairments from brain injury and neurodegenerative diseases through cannabinoid system modulation—evidence …

D Calina, AM Buga, M Mitroi, A Buha… - Journal of Clinical …, 2020 - mdpi.com
Neurological disorders such as neurodegenerative diseases or traumatic brain injury are
associated with cognitive, motor and behavioural changes that influence the quality of life of …

Effect of ultra-micronized palmitoylethanolamide and luteolin on olfaction and memory in patients with long COVID: results of a longitudinal study

P De Luca, A Camaioni, P Marra, G Salzano… - Cells, 2022 - mdpi.com
In this study, we investigated whether treatment with palmitoylethanolamide and luteolin
(PEA-LUT) leads to improvement in the quantitative or qualitative measures of olfactory …

Flavonoids, the compounds with anti-inflammatory and immunomodulatory properties, as promising tools in multiple sclerosis (MS) therapy: a systematic review of …

P Bayat, M Farshchi, M Yousefian, M Mahmoudi… - International …, 2021 - Elsevier
Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal
model of MS, are diseases resulting in neurological disabilities that are regarded as chronic …

Dietary polyphenols, microbiome, and multiple sclerosis: From molecular anti-inflammatory and neuroprotective mechanisms to clinical evidence

G La Rosa, MS Lonardo, N Cacciapuoti… - International Journal of …, 2023 - mdpi.com
Multiple sclerosis (MS) is a multifactorial, immune-mediated disease caused by complex
gene-environment interactions. Dietary factors modulating the inflammatory status through …

Palmitoylethanolamide: A nutritional approach to keep neuroinflammation within physiological boundaries—A systematic review

S Petrosino, A Schiano Moriello - International Journal of Molecular …, 2020 - mdpi.com
Neuroinflammation is a physiological response aimed at maintaining the homodynamic
balance and providing the body with the fundamental resource of adaptation to endogenous …

Hepatoprotective effects of bioflavonoid luteolin using self-nanoemulsifying drug delivery system

F Shakeel, MM Alamer, P Alam, A Alshetaili, N Haq… - Molecules, 2021 - mdpi.com
Luteolin (LUT) is a natural pharmaceutical compound that is weakly water soluble and has
low bioavailability when taken orally. As a result, the goal of this research was to create self …

Effects of palmitoylethanolamide on neurodegenerative diseases: a review from rodents to humans

E Landolfo, D Cutuli, L Petrosini, C Caltagirone - Biomolecules, 2022 - mdpi.com
Palmitoylethanolamide (PEA) stands out among endogenous lipid mediators for its
neuroprotective, anti-inflammatory, and analgesic functions. PEA belonging to the N …

Therapeutic efficacy of palmitoylethanolamide and its new formulations in synergy with different antioxidant molecules present in diets

AF Peritore, R Siracusa, R Crupi, S Cuzzocrea - Nutrients, 2019 - mdpi.com
The use of a complete nutritional approach seems increasingly promising to combat chronic
inflammation. The choice of healthy sources of carbohydrates, fats, and proteins, associated …

Palmitoylethanolamide counteracts enteric inflammation and bowel motor dysfunctions in a mouse model of Alzheimer's disease

V D'Antongiovanni, C Pellegrini, L Antonioli… - Frontiers in …, 2021 - frontiersin.org
Palmitoylethanolamide (PEA), an endogenous lipid mediator, is emerging as a promising
pharmacological agent in multiple neurodegenerative disorders for its anti-inflammatory and …