Customizing cellular signal processing by synthetic multi-level regulatory circuits

Y Gao, L Wang, B Wang - Nature Communications, 2023 - nature.com
As synthetic biology permeates society, the signal processing circuits in engineered living
systems must be customized to meet practical demands. Towards this mission, novel …

Multi-Layer Autocatalytic Feedback Enables Integral Control Amidst Resource Competition and Across Scales

A M. Zand, S Anastassov, T Frei, M Khammash - bioRxiv, 2024 - biorxiv.org
Integral feedback control strategies have proven effective in regulating protein expression in
unpredictable cellular environments. These strategies, grounded in model-based designs …