Despite potent suppression of HIV-1 viral replication in the central nervous system (CNS) by
antiretroviral therapy (ART), between 15% and 60% of HIV-1-infected patients receiving ART …

The most studied HIV eradication approach is the “shock and kill” strategy, which aims to
reactivate the latent reservoir by latency reversing agents (LRAs) and allowing elimination of …

The achievement of an HIV cure is dependent on the eradication or permanent silencing of
HIV-latent viral reservoirs, including the understudied central nervous system (CNS) …

ABSTRACT HIV-1 infection within the central nervous system (CNS) includes evolution of
the virus, damaging inflammatory cascades, and the involvement of multiple cell types; …

Abstract Purpose of Review Deep tissue HIV reservoirs, especially within the central
nervous system (CNS), are understudied due to the challenges of sampling brain, spinal …

Microglia, the main immune modulators of the central nervous system, have key roles in both
the developing and adult brain. These functions include shaping healthy neuronal networks …

Microglia, the resident macrophage of the central nervous system, are increasingly
recognized as contributing to diverse aspects of human development, health, and disease …

The brain is one of the important reservoir sites for HIV persistent/latent infection that often
leads to HIV-associated neurocognitive disorders (HAND). However, HIV dynamics in the …

The HIV-1 often evades a robust antiretroviral-mediated immune response, leading to
persistent infection within anatomically privileged sites including the CNS. Continuous low …

As a key immune cell in the brain, microglia are essential for protecting the central nervous
system (CNS) from viral infections, including HIV. Microglia possess functional Toll‐like …