Essential genes are critical for the growth and survival of any organism. The machine
learning approach complements the experimental methods to minimize the resources …

At the initial stage of drug discovery, identifying novel targets with maximal efficacy and
minimal side effects can improve the success rate and portfolio value of drug discovery …

Schistosomiasis is a neglected tropical disease caused by blood flukes (genus
Schistosoma; schistosomes) and affecting 200 million people worldwide. No vaccines are …

Genomic analyses are yielding a host of new information on the multiple genetic
abnormalities associated with specific types of cancer. A comprehensive description of …

Parasitic diseases have a devastating, long-term impact on human health, welfare and food
production worldwide. More than two billion people are infected with geohelminths …

Toxocara canis is a zoonotic parasite of major socioeconomic importance worldwide. In
humans, this nematode causes disease (toxocariasis) mainly in the under-privileged …

The heartworm Dirofilaria immitis is an important parasite of dogs. Transmitted by
mosquitoes in warmer climatic zones, it is spreading across southern Europe and the …

Background The increased sequencing of pathogen genomes and the subsequent
availability of genome-scale functional datasets are expected to guide the experimental …

Due to major problems with drug resistance in parasitic nematodes of animals, there is a
substantial need and excellent opportunities to develop new anthelmintics via genomic …

Metalloenzymes are central to the regulation of a wide range of essential viral and parasitic
functions, including protein degradation, nucleic acid modification, and many others. Given …