The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in
kidney and cardiovascular research. Genome-wide association studies discovered variants …

The identification of genetic factors associated with the risk, onset, and progression of kidney
disease has the potential to provide mechanistic insights and therapeutic perspectives. In …

Background Uromodulin, the most abundant protein excreted in normal urine, plays major
roles in kidney physiology and disease. The mechanisms regulating the urinary excretion of …

Estimated glomerular filtration rate (eGFR) impacts the concentration of plasma biomarkers
confounding biomarker association studies of eGFR with reverse causation. To identify …

Confounding is major limitation of observational studies. Mendelian randomization (MR) is a
powerful study design that uses genetic variants as instrumental variables to enable …

Blood pressure is regulated by a complex neurohumoral system including the renin-
angiotensin-aldosterone system, natriuretic peptides, endothelial pathways, the sympathetic …

Background Uromodulin is a protein made only by the kidney and released in urine,
circulating in polymerizing and nonpolymerizing forms. This protein's multiple functions …

Background: Salt sensitivity of blood pressure (SSBP) is a trait observed in both humans and
animals, characterized by an increase in blood pressure (BP) following salt loading or a …

Background Chronic kidney disease (CKD) is often accompanied by alterations in the
metabolic profile of the body, yet the causative role of these metabolic changes in the onset …

Background Large increases in glomerular protein filtration induce major changes in body
homeostasis and increase risk of kidney functional decline and cardiovascular disease. We …