Host-directed antiviral therapy

N Kumar, S Sharma, R Kumar, BN Tripathi… - Clinical microbiology …, 2020 - Am Soc Microbiol
Antiviral drugs have traditionally been developed by directly targeting essential viral
components. However, this strategy often fails due to the rapid generation of drug-resistant …

In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2

AM Szemiel, A Merits, RJ Orton, OA MacLean… - PLoS …, 2021 - journals.plos.org
Remdesivir (RDV), a broadly acting nucleoside analogue, is the only FDA approved small
molecule antiviral for the treatment of COVID-19 patients. To date, there are no reports …

Insight into treatment of HIV infection from viral dynamics models

AL Hill, DIS Rosenbloom, MA Nowak… - Immunological …, 2018 - Wiley Online Library
The odds of living a long and healthy life with HIV infection have dramatically improved with
the advent of combination antiretroviral therapy. Along with the early development and …

Edible plant sprouts: Health benefits, trends, and opportunities for novel exploration

SO Aloo, FK Ofosu, SM Kilonzi, U Shabbir, DH Oh - Nutrients, 2021 - mdpi.com
The consumption of plant sprouts as part of human day-to-day diets is gradually increasing,
and their health benefit is attracting interest across multiple disciplines. The purpose of this …

Potential and action mechanism of favipiravir as an antiviral against Junin virus

VR Zadeh, TO Afowowe, H Abe, S Urata… - PLoS …, 2022 - journals.plos.org
Favipiravir is a nucleoside analogue that inhibits the replication and transcription of a broad
spectrum of RNA viruses, including pathogenic arenaviruses. In this study, we isolated a …

Smart and sustainable nanotechnological solutions in a battle against COVID-19 and beyond: a critical review

AM Jastrzebska, AS Vasilchenko - ACS Sustainable Chemistry & …, 2021 - ACS Publications
The variety of available biocidal features make nanomaterials promising for fighting
infections. To effectively battle COVID-19, categorized as a pandemic by the World Health …

The effect of delay in viral production in within-host models during early infection

F Bai, KES Huff, LJS Allen - Journal of biological dynamics, 2019 - Taylor & Francis
Delay in viral production may have a significant impact on the early stages of infection.
During the eclipse phase, the time from viral entry until active production of viral particles, no …

The challenge of quantifying synchrony in malaria parasites

MA Greischar, SE Reece, NJ Savill, N Mideo - Trends in parasitology, 2019 - cell.com
Malaria infection is often accompanied by periodic fevers, triggered by synchronous cycles
of parasite replication within the host. The degree of synchrony in parasite development …

[HTML][HTML] Amazonian medicinal plants efficiently inactivate Herpes and Chikungunya viruses

CP Pavi, I Dai Prá, RD Cadamuro, I Kanzaki… - Biomedicine & …, 2023 - Elsevier
The Amazonian species investigated in this research are commonly utilized for their anti-
inflammatory properties and their potential against various diseases. However, there is a …

Synchronization of Mycobacterium life cycle: A possible novel mechanism of antimycobacterial drug resistance evolution and its manipulation

H Verma, A Chauhan, A Kumar, M Kumar, K Kanchan - Life Sciences, 2024 - Elsevier
Abstract Mycobacterium Tuberculosis (Mtb) causing Tuberculosis (TB) is a widespread
disease infecting millions of people worldwide. Additionally, emergence of drug resistant …