Fluorescence correlation spectroscopy (FCS) is a single molecule sensitive tool for the
quantitative measurement of biomolecular dynamics and interactions. Improvements in …

The apelin receptor (APJ) is a member of the family A of G-protein-coupled receptors
(GPCRs) and is involved in range of physiological and pathological functions, including fluid …

Organogenesis during embryonic development occurs through the differentiation of
progenitor cells. This process is extraordinarily accurate, but the mechanisms ensuring high …

Abstract ELABELA (ELA), a 32-residue hormone peptide abundantly expressed in adult
kidneys, has been identified as a novel endogenous ligand for APJ/Apelin receptor. The aim …

The G protein‐coupled receptor APJ and its cognate ligand, apelin, are widely expressed
throughout human body. They are implicated in different key physiological processes such …

Pregnancy is a dynamic and precisely organized process during which one or more baby
develops. Embryonic development relies on the formation of the placenta, allowing nutrient …

The apelinergic system comprises two peptide ligands, apelin and ELABELA, and their
cognate G-protein-coupled receptor, the apelin receptor APJ. Apelin is a peptide that was …

The apelinergic system, which includes the apelin receptor (APJ) as well as its two specific
ligands, namely apelin and ELABELA (ELA/APELA/Toddler), have been the subject of many …

In the earliest stages of animal development following fertilization, maternally deposited
mRNAs direct biological processes to the point of zygotic genome activation (ZGA). These …

Early embryonic development depends on proper utilization and clearance of maternal
transcriptomes. How these processes are spatiotemporally regulated remains unclear. Here …