A decade of pig genome sequencing: a window on pig domestication and evolution

MAM Groenen - Genetics Selection Evolution, 2016 - Springer
Insight into how genomes change and adapt due to selection addresses key questions in
evolutionary biology and in domestication of animals and plants by humans. In that regard …

Miniature swine for preclinical modeling of complexities of human disease for translational scientific discovery and accelerated development of therapies and medical …

DT Schomberg, A Tellez, JJ Meudt… - Toxicologic …, 2016 - journals.sagepub.com
Noncommunicable diseases, including cardiovascular disease, diabetes, chronic respiratory
disease, and cancer, are the leading cause of death in the world. The cost, both monetary …

The microminipig as an animal model for influenza A virus infection

K Iwatsuki-Horimoto, N Nakajima, M Shibata… - Journal of …, 2017 - Am Soc Microbiol
Pigs are considered a mixing vessel for the generation of novel pandemic influenza A
viruses through reassortment because of their susceptibility to both avian and human …

GHR-mutant pig derived from domestic pig and microminipig hybrid zygotes using CRISPR/Cas9 system

F Tanihara, M Hirata, Z Namula, M Wittayarat… - Molecular Biology …, 2023 - Springer
Background Pigs are excellent large animal models with several similarities to humans.
They provide valuable insights into biomedical research that are otherwise difficult to obtain …

Profiles of reproductive hormone in the microminipig during the normal estrous cycle

M Noguchi, N Miura, T Ando, C Kubota, S Hobo… - in vivo, 2015 - iv.iiarjournals.org
We investigated changes in the peripheral plasma concentrations of ovarian steroids and
gonadotropins throughout the estrous cycle of the Microminipig (MMpig), a novel …

Pathological Characterization of Spontaneous AA Amyloidosis in Microminipigs

M Inoue, S Miyazaki, N Kobayashi… - Toxicologic …, 2023 - journals.sagepub.com
The minipig has been used as a non-rodent species in nonclinical toxicology studies, but
little is known about amyloid A (AA) amyloidosis in this species. Among domestic pigs …

Diurnal variation of melatonin concentration in the cerebrospinal fluid of unanesthetized microminipig

M Abe, H Kawaguchi, N Miura, K Akioka, M Ushikai… - in vivo, 2018 - iv.iiarjournals.org
Background/Aim: The aim of this study was to develop a method for sequentially collecting
cerebrospinal fluid (CSF) from an unanesthetized microminipig, which shares many …

High pathological reproducibility of diet-induced atherosclerosis in microminipigs via cloning technology

M Otake, H Kawaguchi, S Enya, A Kangawa, T Koga… - in vivo, 2021 - iv.iiarjournals.org
Background/Aim: The reproducibility of athero–sclerotic lesions was evaluated after the
production of cloned-microminipigs and their offspring. Materials and Methods: Cloned …

Analysis of gene expression for microminipig liver transcriptomes using parallel long‐read technology and short‐read sequencing

C Sakai, S Iwano, M Shimizu, J Onodera… - … & Drug Disposition, 2016 - Wiley Online Library
The microminipig is one of the smallest minipigs that has emerged as a possible
experimental animal model, because it shares many anatomical and/or physiological …

Estrus synchronization in microminipig using estradiol dipropionate and prostaglandin F2α

M Noguchi, T Ikedo, H Kawaguchi… - Journal of Reproduction …, 2016 - jstage.jst.go.jp
The induction of pseudopregnancy by the exogenous administration of estradiol
dipropionate (EDP) was investigated in cyclic Microminipigs (MMpigs) and the effects of …