The multifaceted biology of PCSK9
NG Seidah, A Prat - Endocrine reviews, 2022 - academic.oup.com
This article reviews the discovery of PCSK9, its structure–function characteristics, and its
presently known and proposed novel biological functions. The major critical function of …
presently known and proposed novel biological functions. The major critical function of …
The proprotein convertases in hypercholesterolemia and cardiovascular diseases: emphasis on proprotein convertase subtilisin/kexin 9
The secretory proprotein convertase (PC) family comprises nine members, as follows:
PC1/3, PC2, furin, PC4, PC5/6, paired basic amino acid cleaving enzyme 4, PC7, subtilisin …
PC1/3, PC2, furin, PC4, PC5/6, paired basic amino acid cleaving enzyme 4, PC7, subtilisin …
Structural and molecular basis for Ebola virus neutralization by protective human antibodies
Ebola virus causes hemorrhagic fever with a high case fatality rate for which there is no
approved therapy. Two human monoclonal antibodies, mAb100 and mAb114, in …
approved therapy. Two human monoclonal antibodies, mAb100 and mAb114, in …
A cholesterol-lowering VLP vaccine that targets PCSK9
E Crossey, MJA Amar, M Sampson, J Peabody… - Vaccine, 2015 - Elsevier
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secretory protein that controls
cholesterol homeostasis by enhancing endosomal and lysosomal degradation of the low …
cholesterol homeostasis by enhancing endosomal and lysosomal degradation of the low …
Molecular and cellular function of the proprotein convertase subtilisin/kexin type 9 (PCSK9)
R Schulz, KD Schlüter, U Laufs - Basic research in cardiology, 2015 - Springer
The proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising
treatment target to lower serum cholesterol, a major risk factor of cardiovascular diseases …
treatment target to lower serum cholesterol, a major risk factor of cardiovascular diseases …
Novel strategies to target proprotein convertase subtilisin kexin 9: beyond monoclonal antibodies
Since the discovery of the role of proprotein convertase subtilisin kexin 9 (PCSK9) in the
regulation of low-density lipoprotein cholesterol (LDL-C) in 2003, a paradigm shift in the …
regulation of low-density lipoprotein cholesterol (LDL-C) in 2003, a paradigm shift in the …
The PCSK9 discovery, an inactive protease with varied functions in hypercholesterolemia, viral infections, and cancer
NG Seidah - Journal of Lipid Research, 2021 - ASBMB
In 2003, the sequences of mammalian proprotein convertase subtilisin/kexin type 9 (PCSK9)
were reported. Radiolabeling pulse-chase analyses demonstrated that PCSK9 was …
were reported. Radiolabeling pulse-chase analyses demonstrated that PCSK9 was …
Physiological and therapeutic regulation of PCSK9 activity in cardiovascular disease
Ischemic heart disease is the main cause of death worldwide and is accelerated by
increased levels of low-density lipoprotein cholesterol (LDL-C). Proprotein convertase …
increased levels of low-density lipoprotein cholesterol (LDL-C). Proprotein convertase …
Polydatin ameliorates lipid and glucose metabolism in type 2 diabetes mellitus by downregulating proprotein convertase subtilisin/kexin type 9 (PCSK9)
Y Wang, J Ye, J Li, C Chen, J Huang, P Liu… - Cardiovascular …, 2016 - Springer
Background Abnormalities in lipid and glucose metabolism are constantly observed in type
2 diabetes. However, these abnormalities can be ameliorated by polydatin. Considering the …
2 diabetes. However, these abnormalities can be ameliorated by polydatin. Considering the …
Sorting an LDL receptor with bound PCSK9 to intracellular degradation
TP Leren - Atherosclerosis, 2014 - Elsevier
Objective This article reviews the mechanism by which the low density lipoprotein receptor
(LDLR) that has bound proprotein convertase subtilisin/kexin type 9 (PCSK9), is rerouted to …
(LDLR) that has bound proprotein convertase subtilisin/kexin type 9 (PCSK9), is rerouted to …